Synthesis, antitumor activity and crystallographic studies of analogues of tiazofurin

Article abstract of DOI:10.1080/15257779508012440

The syntheses and antitumor activity of 2-β-D-ribofuranosylfuran-4- carboxamide (furanfurin) and 2-β-D-ribofuranosylthiophene-4-carboxamide (thiophenfurin) are reported. The X-ray structure of ethyl 2-β-D- ribofuranosylthiophene-4-carboxylate, precursor of thiophenfurin, is also presented. Only thiophenfurin showed activity as an antitumor agent both in vitro and in vivo.

Full text of DOI:10.1080/15257779508012440

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Nucleosides and Nucleotides
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Synthesis, Antitumor Activity and
Crystallographic Studies of Analogues of
Tiazofurin
L. Cappellacci a , P. Franchetti a , M. Grifantini a , L. Messini a , G.
Abu Sheikha a , G. Nocentini b , R. Moraca b & B. M. Goldstein c
a Dipartimento di Scienze Chimiche , Università di Camerino , 62032,
Camerino, Italy
b Dipartimento di Medicina Clinica, Patologia e Farmacologia ,
Universitág di Perugia , 06100, Perugia, Italy
c Department of Biophysics , University of Rochester Medical
Center , Rochester, New York, 14642, USA
Published online: 16 Feb 2007.
To cite this article: L. Cappellacci , P. Franchetti , M. Grifantini , L. Messini , G. Abu Sheikha , G.
Nocentini , R. Moraca & B. M. Goldstein (1995) Synthesis, Antitumor Activity and Crystallographic
Studies of Analogues of Tiazofurin, Nucleosides and Nucleotides, 14:3-5, 637-640
To link to this article: http://dx.doi.org/10.1080/15257779508012440
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