The authors are particularly thankful to Dr. Bruce Seely for his
ongoing support of our work.
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Fig. 6. Proposed acting mechanism of MitoProbe.
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Fig. 7. Predicted lowest energy conformations of MitoProbes I/II.
In conclusion, the development of MitoProbes that specifically
accumulate within mitochondria coupled to the capacity to monitor
mitochondrial oxidative stress via real-time imaging microscopy, will
greatly improve our understanding of mitochondrial function,
morphology and dynamics. These tools, and their further
development, will lead to a more comprehensive understanding of
the molecular basis of mitochondrial dynamics and its impairment in
different diseases, leading to more targeted therapeutic strategies. The
continued success of our work will also extend a pathway to imaging
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diseases, even in the post-mortem state.
Acknowlegment. L.B. is grateful to NIH (GM088795-01), NSF (No.
1048655), NASA (# MSGC R85197), MIIE (#1204010), VPR-SI fund
(#R01386), and the Research Excellence Fund (#R01121 and #R01323).
(26). Dickinson, B. C.; Lin, V. S.; Chang, C. J. Nat.
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