The First Example of Asymmetric Dihydroxylation of Cyclopropylidene Derivatives --- An Enantioenriched Formal Total Synthesis of (-)-Filiformin

Article abstract of DOI:10.1016/0040-4039(94)02452-H

The first example of asymmetric dihydroxylation (AD) of the cyclopropylidene derivatives 4a-e followed by enantiospecific 1,2-rearrangement of the resulted diols 5a-e to give the optically active cyclobutanones 7a-e was reported.The synthesis of 7e consti