Asymmetric Conjugate Addition of Grignard Reagents in the Presence of Tertiary Amines to α,β-Unsaturated Amides Derived from (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine or (S)-Prolinol

DOI: 10.1039/c39850000469

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 469 - 470 (1985)

Update date:2022-08-29

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Authors:

Soai, Kenso

Machida, Hideaki

Ookawa, Atsuhiro

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Article abstract of DOI:10.1039/c39850000469

In the presence of tertiary amines, diastereoselective conjugate addition of Grignard reagents to α,β-unsaturated amides affords 3-substituted carboxylic acids of high enantiomeric excess (up to 89percent e.e.).

Full text of DOI:10.1039/c39850000469

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