Carboxylation of Phenols with CO2 at Atmospheric Pressure

Article abstract of DOI:10.1002/chem.201601114

A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO₂ pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO₂. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO₂ at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.

Full text of DOI:10.1002/chem.201601114

DOI: 10.1002/chem.201601114
Communication
&
Carboxylation
Carboxylation of Phenols with CO2 at Atmospheric Pressure
Junfei Luo,[a, b] Sara Preciado,[b] Pan Xie,[a] and Igor Larrosa*[a]
Abstract: A convenient and efficient method for the
ortho-carboxylation of phenols under atmospheric CO2
pressure has been developed. This method provides an al-
ternative to the previously reported Kolbe–Schmitt
method, which requires very high pressures of CO2. The
addition of a trisubstituted phenol has proved essential
for the successful carboxylation of phenols with CO2 at
standard atmospheric pressure, allowing the efficient
preparation of a broad variety of salicylic acids.
Scheme 1. Carboxylation of phenols.
The formation of CÀC bonds to build complexity from avail-
able chemical feedstocks is a fundamental goal of organic
chemistry.[1] In this regard, the development of methodologies
backs, which can make its application difficult in some labora-
for the transformation of CO2, a green carbon source that is
highly abundant in the atmosphere as well as non-toxic, into
valuable organic compounds is of great interest.[2] A simplest
such reaction is the formation of carboxylic acids by carboxyla-
tion of organic molecules with CO2. Numerous methodologies
have been developed for the carboxylation of different organ-
ometallic reagents in the past.[3] More recently, a breakthrough
on the transition-metal-catalysed reductive carboxylation of
readily available starting materials, such as aryl or benzyl hal-
ides and phenol derivatives, has provided an alternative for
the synthesis of carboxylic acid derivatives.[4] Similarly, the de-
velopment of direct CÀH carboxylation methods has also been
of great interest due to their significance from a step- and
atom-economical point of view.[5]
tories: 1) High CO2 pressure (20–100 atm) and temperature
(130–2808C) are generally required to achieve good conver-
sion. Even though one and a half centuries have passed since
the original reports, no method has been reported for the effi-
cient carboxylation of phenols proceeding under atmospheric
CO2 pressure; 2) The preparation and isolation of completely
dry phenoxide from the corresponding phenol is necessary, as
the presence of water inhibits the Kolbe–Schmitt carboxyla-
tion;[9] 3) Conditions vary over a wide range of pressures, tem-
peratures and reaction times, depending on the phenol
used.[10]
Herein, we report the first example of the Kolbe–Schmitt car-
boxylation that is able to proceed efficiently at atmospheric
CO2 pressure for a variety of phenol substrates. We found that
using 2,4,6-trimethylphenol as a recyclable additive proved key
for this carboxylation, significantly increasing the initial reac-
tion rate as well as improving the final yield of the carboxyla-
tion. This method provides a straightforward access to salicylic
acids by avoiding the isolation of the phenoxide and the re-
quirement of high-pressure reaction equipment. Moreover,
unlike the classic Kolbe–Schmitt method, in which the condi-
tions significantly vary for different starting materials, our
method allows the transformation of a variety of phenols into
the corresponding salicylic acids in good yields under unified
conditions (Scheme 1b).
The Kolbe–Schmitt reaction is one of the most important
and well-known carboxylation reactions, providing direct
access to salicylic acids by the ortho CÀH carboxylation of
phenoxides with CO2 (Scheme 1a).[6] Salicylic acids are impor-
tant motifs in pharmaceuticals, agrochemicals, advanced mate-
rials, as well as important intermediates in organic synthesis.[7]
Owing to the low cost of such method, the Kolbe–Schmitt re-
action is widely used in industry, most notably for the synthe-
sis of aspirin.[8] However, this process still presents some draw-
[a] J. Luo, P. Xie, Prof. I. Larrosa
We started our investigation by studying the carboxylation
of o-cresol (1a) with 1 atm of CO2 at 1858C in the absence of
solvent (Table 1). A screening of bases revealed that neither
NaOH nor KOH, the two most commonly used bases in the
Kolbe–Schmitt reaction, led to any reactivity in a one-pot pro-
cess without the isolation of the phenoxide intermediate (en-
tries 1 and 2). Alkali-metal carbonates have also been reported
to be useful bases in the Kolbe–Schmitt reaction.[11] However,
School of Chemistry, University of Manchester
Oxford Road, Manchester, M13 9PL (UK)
E-mail: igor.larrosa@manchester.ac.uk
[b] J. Luo, S. Preciado
School of Biological and Chemical Sciences
Queen Mary University of London
Joseph Priestley Building, Mile End Road, E1 4NS, London (UK)
Supporting information for this article is available on the WWW under
http://dx.doi.org/10.1002/chem.201601114.
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Table 1. Screening of bases.[a]
Table 2. Screening of phenol additives.[a]
Entry
Base (equiv)
Yield 2a [%]
Yield 3a [%]
1
2
3
4
5
6
7
8[b]
KOH (1.0)
NaOH (1.0)
K2CO3 (1.0)
Na2CO3 (1.0)
NaH (1.0)
NaH (2.0)
NaH (3.0)
NaH (2.0)
0
0
1
0
32
38
39
39
0
0
0
0
2
2
3
2
Entry
Additive (equiv)
Yield 2a [%]
Yield 3a [%]
1[b]
2
3
4
5
6
7
8[c]
9[d,e]
–
38
53
37
36
40
82
76
74
62
2
5
3
2
4 (1.0)
5 (1.0)
6 (1.0)
7 (1.0)
8 (1.0)
8 (0.5)
8 (1.0)
8 (1.0)
[a] Reactions were carried out with 0.25 mmol of 1a. The mixture was ini-
tially heated at 1008C for 5 min in order to form the potassium or
sodium 2-methylphenolate, following by heating at 1858C under CO2 at-
mosphere; yields were determined by 1H NMR analysis using 1,3,5-trime-
thoxybenzene as an internal standard. [b] The reaction was carried out
for 4 h.
5
12
11
11
10
[a] Reactions were carried out with 0.25 mmol of 1a. The reaction mixture
was heated at 1008C for 5 min in order to form sodium phenoxides
before heating at 1858C under CO2 atmosphere; yields were determined
by 1H NMR analysis using 1,3,5-trimethoxybenzene as an internal stan-
dard. [b] 2.0 equiv of NaH was used. [c] 3.0 equiv of NaH was used.
[d] The reaction was performed at 1608C. [e] Extending the reaction time
to 3 h showed no improvement in yield.
only 1% of the desired product 2a was obtained when K2CO3
was employed (entry 3) and no product was observed when
using Na2CO3 (entry 4). Finally, NaH was chosen so as to avoid
the formation of water during the deprotonation of o-cresol
(1a). Gratifyingly, 32% of ortho-carboxylated product 2a and
2% of para-carboxylated product 3a were obtained when
one equivalent of NaH was used (entry 5). Doubling the
amount of NaH to two equivalents increased the yield to 38%
(entry 6). However, a further increase in the amount of NaH
(entry 7) afforded no further improvement in the yield. Finally,
prolonged reaction times did not increase conversion (entry 8).
It has been proposed that CO2 could be captured by a metal
phenolate through weak coordination between the alkali
metal and CO2.[12] We therefore speculated that the carboxyla-
tion could be promoted by the use of an additional “support-
ing” phenolate, through an increased CO2 absorption. Howev-
er, this phenolate should not be able to undergo carboxylation
itself so as to avoid the consumption of the absorbed CO2.
Thus, we set on investigating whether 2,4,6-trisubstituted phe-
nolates, with their ortho- and para-positions blocked, would be
suitable additives for this purpose (Table 2). Gratifyingly, an im-
provement in the yield was obtained by the addition of one e-
quivalent of 2,6-di-tert-butyl-4-methoxyphenol (4), in the pres-
ence of four equivalents of NaH, affording 53% of the desired
ortho-carboxylated product 2a and 5% of para-carboxylated
product 3a (entry 2). Encouraged by this result, substituted
phenols 5 and 6 with tert-butyl at both ortho-positions were
tested but no improvement in the yield was observed (en-
tries 3 and 4). The more electron-deficient 2,4,6-trifluorophenol
(7) afforded a similar result (entry 5). Gratifyingly, the electron-
rich but less sterically hindered 2,4,6-trimethylphenol (8) led to
a significant improvement in the yield, with a total of 94% car-
boxylation and an 82% of 2a (entry 6). Further efforts towards
reducing the amount of phenol additive 8 or NaH, and the
temperature led to lower yields (entries 7–9). The previous
report of the carboxylation of 1a required 80–140 atm of CO2
to afford 70% yield.[10a]
In order to evaluate the magnitude of the effect of adding
2,4,6-trimethylphenol (8), we studied the kinetic profile of the
carboxylation in the presence and absence of this additive
(Figure 1). It was found that the carboxylation is rapid at the
beginning of the reaction with a significant decrease in reac-
tion rate after 1 h. The addition of 8 significantly increases the
initial reaction rate as well as improving the final yield of the
carboxylation, indicating that 2,4,6-trimethylphenol (8) plays an
important role in facilitating the carboxylation reaction.
Having found suitable conditions for an atmospheric pres-
sure Kolbe–Schmitt carboxylation, a variety of substituted phe-
nols were tested to investigate the generality of this process
(Scheme 2). Substrates with alkyl substituents at the ortho-,
Figure 1. Kinetic profile of the carboxylation process (yield of 2a+3a) in
the absence (black diamonds) and in the presence (grey triangles) of one e-
quivalent of 2,4,6-trimethylphenol (8).
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This methodology is amenable to scaling up. Applying the
standard conditions, without any modification, to the ortho-
carboxylation of 3-tert-butylphenol (1h) on a 7.0 mmol (1.05 g)
scale afforded the corresponding salicylic acid 2h in 93% yield.
Importantly, the additive 2,4,6-trimethylphenol (8) can be
easily recovered after the reaction and recycled (Scheme 3).
Scheme 3. Gram-scale synthesis. Yields are of isolated pure material.
We set out to further understand how 2,4,6-trimethylphenol
(8) is able to facilitate the atmospheric pressure carboxylation
reaction. Given that the carboxylation reaction would be de-
pendent on the rate of mixing between the gas and solid
phase, we hypothesized that 8 might be acting as a mixing
aid, consequently promoting the carboxylation by increasing
the surface area of the solid. Glass beads have been found to
significantly improve the outcome of heterogeneous reac-
tions.[13] Thus, we tested the carboxylation of 1a in the pres-
ence of glass beads, instead of phenol additive 8. However, no
effect on the yield of the reaction was observed, with 36% of
2a obtained after 2 h of reaction (compare to Table 1,
entry 6).[14] This result suggests that 8 does not act as a mixing
aid and instead may play a role in facilitating CO2 fixation and
delivery to the reactive phenoxide.
Scheme 2. Scope of phenol carboxylation. Reactions were carried out with
0.25 mmol of phenol 1. Yields are of the isolated pure material. [a] The reac-
tion was carried out at 5 atm of CO2. [b] The reaction was carried out for
16 h.
It is generally accepted that in the Kolbe–Schmitt reaction,
monosodium salicylate (12) is formed by the sodium phenox-
ide–CO2 complex 11 (Scheme 5).[12,15,16] To probe this, we first
mixed the phenol 1a and NaH to form sodium phenoxide 9,
and then left the mixture under atmospheric CO2 pressure at
room temperature for 1 h to allow the CO2 fixation
(Scheme 4a). The CO2 was then replaced with argon and the
mixture was heated at 1858C for 20 min, affording 10% of
product 2a and 1% of 3a. This suggests that CO2 is “fixed”
meta- and para-positions were all ortho-carboxylated in good
yields (Scheme 2; 2a–h, 2k, 2m), with even the highly hin-
dered 3,5-dimethylphenol affording 37% of carboxylated prod-
uct 2 f. Interestingly, with m-cresol (1b) a mixture of C6- and
C2-carboxylated products in an 85:15 ratio was obtained
(Scheme 2; 2b). A similar pattern was seen with bicyclic
phenol 1m (2m). Conversely, increased steric hindrance at C3
prevented the formation of C2-carboxylated product 2h. How-
ever, comparable substrates with ether substituents at the
meta-position underwent ortho-carboxylation, with only one
regioisomer being obtained (2i and 2l). The electron-donating
functionality NMe2 was also found to be suitable in this
method, leading to good yields (2j). Simple phenol was also
carboxylated in good yield, affording 64% of salicylic acid (2n).
It was gratifying that electron-withdrawing halogen groups,
such as Cl and Br, at C3 and C4 were also compatible with this
methodology (2p–r). In the case of 2-chlorophenol, a slightly
higher CO2 pressure was required for the carboxylation to pro-
ceed (2o). No carboxylation product was observed when
a phenol containing the strongly electron-withdrawing nitro
group was used (2s), leading to unreacted starting material. Fi-
nally, the steroid hormone estrone 1t was found to be conven-
iently converted to the ortho-carboxylated product 2t in 53%
yield and with complete regioselectivity.
Scheme 4. Investigation on the effect of 8 in the absence of CO2 atmos-
1
phere. Yields are measured by H NMR using an internal standard.
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0.25 mmol, 1.0 equiv). The resulting mixture was heated at 1008C
for 5 min, cooled down to room temperature and grinded to
powder with the use of a spatula. The vial with the mixture was
taken out from the glove box, purged with CO2 and reacted with
a balloon filled with CO2 at 1858C for 2 h. After this time, the reac-
tion mixture was cooled to room temperature, carefully quenched
with H2O (5 mL), acidified to pH 4 with aq. HCl (1m), and then ex-
tracted with EtOAc (3”10 mL). The organic layers were dried over
anhydrous MgSO4, evaporated to dryness and purified by column
chromatography to afford the corresponding salicylic acid.
Note: The reaction can be set up without the use of a glove box.
In this case, the grinding of the mixture should be carried out
under a stream of N2 or Ar. Furthermore, we found that the NaH
reagent does not age well, and yields decrease after prolonged
use if handled outside the glove box.
Scheme 5. Mechanistic proposal for the role of 8/10.
(absorbed or adsorbed) by the solid reagents, and that this
fixed CO2 is reactive in the carboxylation conditions. In fact, it
has previously been suggested that only the fixed CO2 is reac-
tive in the carboxylation step, not the gaseous CO2.[12] We set
up a similar reaction, in which a mixture of 8 and NaH was
added under argon after the mixture of 1a and NaH had been
exposed to CO2 (Scheme 4b). An improvement in the yield
was seen, with 22% of 2a and 7% of 3a being obtained after
heating the mixture for 20 min. The addition of excess NaH
without 8, on the other hand, did not improve the yield.[14]
This suggests that 10, formed by pre-mixing 8 with NaH, in-
creases the rate of the carboxylation from 11. Finally, we mixed
both 1a and 8 with excess of NaH, and then exposed the mix-
ture under atmospheric CO2 pressure at room temperature for
1 h, followed by replacement of CO2 with argon and heated
the mixture (Scheme 4c). In this case, a significantly improved
yield was seen, with 60% of 2a and 12% of 3a being ob-
tained. This suggests that in addition to increasing the rate of
the carboxylation from 11, species 10 also increase the
amount of fixed CO2.
Acknowledgements
We gratefully acknowledge the European Research Council for
a Starting Grant (to I.L.), the China Scholarship Council and
Queen Mary University of London for a studentship (to J. L.),
and the Marie Curie Foundation for an Intra-European Fellow-
ship (to S.P.).
Keywords: carbon dioxide · Kolbe–Schmitt reaction · phenols ·
salicylic acids · synthetic methods
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Experimental Section
In the glove box, NaH (60% dispersion in mineral oil, 40 mg,
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Received: March 9, 2016
Published online on March 31, 2016
Chem. Eur. J. 2016, 22, 6798 – 6802
www.chemeurj.org
6802
ꢀ 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim