Studies on quinolone antibacterials. V. Synthesis and antibacterial activity of chiral 5-amino-7-(4-substituted-3-amino-1-pyrrolidinyl)-6- fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acids and derivatives

DOI: 10.1248/cpb.44.1376

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Chemical and Pharmaceutical Bulletin p. 1376 - 1386 (1996)

Update date:2022-08-11

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Authors:

Yoshida, Toshihiko

Yamamoto, Yoichi

Orita, Hitomi

Kakiuchi, Masato

Takahashi, Yoshie

Itakura, Masakazu

Kado, Noriyuki

Yasuda, Shingo

Kato, Hideo

Itoh, Yasuo

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Article abstract of DOI:10.1248/cpb.44.1376

We previously demonstrated that 5-amino-7-(3-amino1l-pyrrolidinyl)-1- cyclopropyl-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid (7) has strong in vitro antibacterial activity even against quinolone-resistant bacteria. We examined optimization of t

Full text of DOI:10.1248/cpb.44.1376

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