A Concise Synthesis of (-)-Dihydroprotolichesterinic Acid via Consecutive Stereocontrolled 1,4-Conjugate Addition and syn-Aldol Condensation Reactions

DOI: 10.1016/0040-4039(95)00560-Y

Source and publish data:

Tetrahedron Letters p. 3567 - 3570 (1995)

Update date:2022-08-28

Topics:

Authors:

Banks, Malcolm R.

Dawson, Ian M.

Gosney, Ian

Hodgson, Philip K. G.

Thorburn, Paul

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Article abstract of DOI:10.1016/0040-4039(95)00560-Y

(-)-Dihydroprotolichesterinic acid 1a is synthesised in 6 steps and 57percent overall yield by a strategy employing the camphene-derived chiral auxiliary 2 to construct the three contiguous stereogenic centres in consecutive stereocontrolled 1,4-conjugate addition and syn-aldol reactions.

Full text of DOI:10.1016/0040-4039(95)00560-Y

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