Synthesis of Functionalized Ring A Building Blocks for Taxoids

Article abstract of DOI:10.1016/0040-4039(95)01244-C

The synthesis of a series of oxygenated cyclohexenes 1, 2, 11, 14, 18, and 19 that possess suitable functionality for further elaboration for taxoid synthesis is described.These compounds have been prepared from β-ionone by a series of oxidative and addition reactions or alternatively by a Lewis acid catalyzed intermolecular Diels-Alder reaction in which the A-ring is constructed directly.