Synthesis of novel functionalized 5-nitroisoquinolines and evaluation of in vitro antimalarial activity

DOI: 10.1016/0223-5234(96)88261-4

Source and publish data:

European Journal of Medicinal Chemistry p. 503 - 508 (1995)

Update date:2022-08-28

Topics:

Authors:

Rathelot

Vanelle Vanelle

Gasquet Gasquet

Delmas Delmas

Crozet Crozet

Timon-David

Maldonado

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Article abstract of DOI:10.1016/0223-5234(96)88261-4

Novel aldimine and hydrazone isoquinoline derivatives were obtained after subjecting 1-formyl-5-nitroisoquinoline to classical reactions. Some of these compounds were found to have activity against a chloroquine-resistant Plasmodium falciparum strain (ACC Niger).

Full text of DOI:10.1016/0223-5234(96)88261-4

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