Directed aminomethylation of 3-hydroxy-2(1H)-pyridinones and 3-hydroxy-4(1H)-pyridinones: Synthesis of iso-deferiprone

Article abstract of DOI:10.1016/0040-4020(95)01016-5

The site of aminomethylation of N-unsubstituted 3-hydroxy-2-(1H)-pyridinones and 3-hydroxy-4(1H)-pyridinones, under Mannich reaction conditions, is directed by the hydroxyl group when this is unprotected and by the keto group when the hydroxyl is protecte