1,1,1-TRICHLORO-3--3,4-EPOXYBUTANE

Article abstract of DOI:10.1016/S0022-1139(00)82748-7

The synthesis of 1,1,1-trichloro-3-<5-(2,4,6-trifluoropyrimidyl)>-3,4-epoxybutane has been accomplished in nine steps from diethyl malonate and urea.The epoxide was prepared from the olefinic precursor via oxidation with anhydrous trifluoroperacetic acid in a non-buffered system.Product isolation from trifluoroacetic acid solution demonstrates an unexpected stability of this class of epoxides toward protonic media.