7790-28-5

Basic information

• Product Name: Sodium periodate
• Synonyms: metaperiodate;periodicacid(hio4),sodiumsalt;Periodicacid,sodiumsalt;sodiummetaperidate;sodiummetaperiodate(sodiumperiodate);IONAM;SODIUM PERIODATE META;SODIUM M-PERIODATE
• CAS NO: 7790-28-5
• Molecular Formula: IO₄*Na
• Molecular Weight: 213.89
• EINECS: 232-197-6
• Product Categories: Inorganics;Oxidizing Agents;Chemical Synthesis;Hypervalent Iodine;Materials Science;Metal and Ceramic Science;Salts;Sodium Salts;Synthetic Reagents;API;Life Science Chemical Reagents;Dyestuff Intermediates
• Mol File: 7790-28-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 300 °C (dec.)(lit.)
• Boiling Point: 300°C
• Appearance: White to almost white/Solid
• Density: 3.865
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: Store at +5°C to +30°C.
• Solubility: H2O: 0.5 M at 20 °C, clear, colorless
• Water Solubility: 80 g/L (20 ºC)
• Sensitive: Hygroscopic
• Stability: Stable. Incompatible with organic materials, combustible materials. Forms explosive mixtures with reducing agents, finely powder
• Merck: 14,8640
• CAS DataBase Reference: Sodium periodate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium periodate(7790-28-5)
• EPA Substance Registry System: Sodium periodate(7790-28-5)

Safety Data

• Hazard Codes: O,Xn,Xi,N,C,T
• Statements: 8-22-36/37/38-20/21/22-50-48/25-34
• Safety Statements: 26-36/37/39-17-61-45-37
• RIDADR: UN 3087 5.1/PG 2
• WGK Germany: 3
• RTECS: SD4550000
• F: 8
• TSCA: Yes
• HazardClass: 5.1
• PackingGroup: II
• Hazardous Substances Data: 7790-28-5(Hazardous Substances Data)

Usage

Description

Sodium periodate is an inorganic salt, composed of a sodium cation and the periodate anion. It may also be regarded as the sodium salt of periodic acid. Like many periodates it can exist in two different forms: sodium metaperiodate, which has the formula NaIO4, and sodium orthoperiodate, normally this means sodium hydrogen periodate (Na2H3IO6) but the fully reacted sodium orthoperiodate salt, Na5IO6, can also be prepared. Both salts are useful oxidising agents.

Chemical Properties

Different sources of media describe the Chemical Properties of 7790-28-5 differently. You can refer to the following data:
1. white powder
2. Sodium periodate Na2H3IO6, is formed by reaction of sodium iodate plus sodium hydroxide plus chlorine (sodium chloride also formed), and the periodate separates as crystals from the medium. In solution, it is stated, periodate gradually forms ozone and iodate at the ordinary temperatures.

Uses

Different sources of media describe the Uses of 7790-28-5 differently. You can refer to the following data:
1. Sodium Periodate is the sodium salt of periodic acid used to oxidize cellulose. Sodium Periodate oxidation is often used to selectively label RNA, saccharides and other compounds with vicinal diols.
2. Oxidimetric standard; determination of manganese.
3. Sodium metaperiodate is used as an oxidizing reagent involved in the oxidation of cellulose. It is involved in the cleavage of vicinal diols to prepare two aldehydes. This oxidation is commonly used in selectively label RNA, saccharides and other compounds with vicinal diols.

Definition

ChEBI: An inorganic sodium salt having periodate as the counterion.

General Description

Sodium periodate (sodium (meta)periodate) supported on silica gel is a solid supported reagent. It may be synthesized by adding silica gel to hot aqueous solution of sodium metaperiodate and evaporating to dryness followed by vigorous swirling and shaking.

Hazard

Fire risk in contact with organic materials. Toxic by ingestion.

Flammability and Explosibility

Nonflammable

Purification Methods

Recrystallise it from hot water. [Willard Inorg Synth I 170 1939, Bernays Inorg Synth II 212 1946.]

InChI:InChI=1/HIO4.Na/c2-1(3,4)5;/h(H,2,3,4,5);/q;+1/p-1

Synthetic route

iodine (7553-56-2) + sodium hydroxide (1310-73-2) → sodium periodate (7790-28-5)

Conditions	Yield
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln.; crystn. at 37°C;
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln.; crystn. at 37°C;

iodine (7553-56-2) + chlorine (7782-50-5) + sodium hydroxide (1310-73-2) → sodium periodate (7790-28-5)

Conditions	Yield
In water passing gaseous Cl2 through a soln. of 20 g I and 80 g NaOH in 300 ml water; crystallization after some hours;; filtration; washing; repeated recrystallization from diluted H2SO4;;

Sodium borate + iodine (7553-56-2) → sodium periodate (7790-28-5)

Conditions	Yield
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln.; crystn. at 37°C;
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln.; crystn. at 37°C;

iodine (7553-56-2) + sodium sulfate (7757-82-6) → sodium periodate (7790-28-5)

Conditions	Yield
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln., neutralization with NaOH soln; crystn. at 37°C;
In not given Electrolysis; NaOH soln. as catholyte and NaOH soln. of I2 as anolyte are separated by permeable diaphragm, PbO2 anode, current density : 0.05-0.3 A/cm2, acidifying of anodic soln., neutralization with NaOH soln; crystn. at 37°C;

sodium peroxide + sodium iodide (7681-82-5) → sodium periodate (7790-28-5)

Conditions	Yield
In neat (no solvent) reaction when heating;;

sodium paraperiodate → sodium periodate (7790-28-5)

Conditions	Yield
With nitric acid In water concd. HNO3 soln. used, standing for 24 h at ambient temp.; washing more times with cold water, drying at 110°C;
With HNO3 In water concd. HNO3 soln. used, standing for 24 h at ambient temp.; washing more times with cold water, drying at 110°C;
With HNO3 In water

sodium periodate trihydrate → sodium periodate (7790-28-5)

Conditions	Yield
In water formation by recrystallization of NaIO4*3H2O from water;;
In neat (no solvent) byproducts: H2O; at 34.5°C;;
In water formation by recrystallization of NaIO4*3H2O from water;;

sodium orthoperiodate + periodic acid (13444-71-8) → sodium periodate (7790-28-5)

Conditions	Yield
In further solvent(s) dissolving Na2H3IO6 in pure HIO4; saturation of the solution; evaporation;;
In further solvent(s) dissolving Na2H3IO6 in pure HIO4; saturation of the solution; evaporation;;

potassium metaperiodate (7790-21-8) → sodium periodate (7790-28-5)

Conditions	Yield
In not given hot KIO4 (6 %) soln. used, cation exchange;

sodium iodate + chlorine (7782-50-5) + sodium hydroxide (1310-73-2) → sodium periodate (7790-28-5) + sodium iodate chloride * 9 H2O

Conditions	Yield
In not given complete crystallization of NaIO4 on passing Cl2 into a solution of NaIO3 and NaOH; crystallization of 2NaIO3*3NaCl*9H2O after complete precipitation of NaIO4;;
In not given complete crystallization of NaIO4 on passing Cl2 into a solution of NaIO3 and NaOH; crystallization of 2NaIO3*3NaCl*9H2O after complete precipitation of NaIO4;;

sodium periodate trihydrate → sodium periodate (7790-28-5) + water (7732-18-5)

Conditions	Yield
In neat (no solvent) dehydration over H2SO4 or on heating at 100 °C;;
In neat (no solvent) dehydration over H2SO4 or on heating at 100 °C;;

sodium iodate → sodium periodate (7790-28-5)

Conditions	Yield
With ozone; sodium hydroxide at 20℃; for 1h; pH=13; pH-value;

sodium periodate (7790-28-5) + 3-(trimethylstannyl)propyl ethyl sulfide (104336-12-1) → 3-(trimethylstannyl)propyl ethyl sulfoxide (104336-13-2)

Conditions	Yield
In methanol; water slow addn. of NaIO4 (in H2O) to Sn-compd. (in MeOH) at 0°C, stirring (0°C, 5 h; then room temp., 18 h); filtration, solvent removal (reduced pressure), distn.; elem. anal.;	99%

sodium periodate (7790-28-5) + trans-dichlorobis(ethylenediamine)cobalt(III) chloride (13408-72-5, 14040-32-5, 14040-33-6, 20594-10-9, 20594-11-0) → trans-dichlorobis(ethylenediamine)cobalt(III) periodate (14587-93-0, 92276-03-4)

Conditions	Yield
In water byproducts: NaCl; the soln. of complex in water was mixed with a soln. of NaIO4 in min water; ppt. was dried in air; elem. anal.;	99%

hydrogenchloride (7647-01-0) + sodium periodate (7790-28-5) + (2,7-di-tert-butyl-5-[4-(methoxycarbonyl)phenyl]-9,9-dimethyl-9H-xanthen-4-yl)boronic acid pinacol ester + water (7732-18-5) → (2,7-di-tert-butyl-5-[4-(methoxycarbonyl)phenyl]-9,9-dimethyl-9H-xanthen-4-yl)boronic acid

Conditions	Yield
Stage #1: sodium periodate; (2,7-di-tert-butyl-5-[4-(methoxycarbonyl)phenyl]-9,9-dimethyl-9H-xanthen-4-yl)boronic acid pinacol ester; water In tetrahydrofuran at 20℃; for 0.5h; Schlenk technique; Inert atmosphere; Stage #2: hydrogenchloride In tetrahydrofuran; water at 20℃; for 12h;	95%

sodium periodate (7790-28-5) + ruthenium trichloride hydrate + tetrapropylammonium hydroxide → tetrapropylammonium perruthennate (114615-82-6)

Conditions	Yield
In water stirring of hydrated RuCl3 and NaIO4 in H2O overnight; addn. to an aq. soln. of n-Pr4NOH containing NaOH at 0-5°C under an atmosphere of O2;; ppt. was removed every 20 min, washed with ice-cold water, and dried under vac.;;	87%

sodium periodate (7790-28-5) + ruthenium trichloride hydrate → hexasodium trans-dioxobis{periodato(4-)-O1O2} rhutenate(VI) *18H2O

Conditions	Yield
In sodium hydroxide aq. NaOH; saturated soln. of NaIO4 was added to soln of RuCl3 in aq. NaOH; filtered, washed with NaOH soln., dried, recrystd. from aq. NaOH, washed with NaOH, elem. anal.;	85%

sodium periodate (7790-28-5) + {CoCO3phan2}Cl*H2O → {CoCO3phan2}IO4

Conditions	Yield
In water byproducts: NaCl; a soln. of Co-complex and NaIO4 in water were mixed, allowed to stand for three hours at room temp.; crystals were collected and dried in air; elem. anal.;	85%

sodium periodate (7790-28-5) + (2,2'-biimidazole(1-))bis(1,10-phenanthroline)cobalt(III)dichloride decahydrate → (2,2'-biimidazole(1-))bis(1,10-phenanthroline)cobalt(III)diperiodate hemihydrate

Conditions	Yield
In water aq. soln. of NaIO4 added to aq. soln. of complex (2:1 mol); product crystd. (MeCN-H2O) at room temp. for 2 d; filtered off; dried inair; elem. anal.;	85%

sodium periodate (7790-28-5) + osmium(VIII) oxide (20816-12-0) + C39H52N8Zn → C35H44N8OZn

Conditions	Yield
With polyvinylpyridine In tetrahydrofuran; water at 20℃; for 16h;	85%

sodium periodate (7790-28-5) + Betulinic acid (472-15-1) → platanic acid (6060-06-6)

Conditions	Yield
Stage #1: Betulinic acid With osmium(VIII) oxide In 1,4-dioxane; water at 20℃; for 1h; Stage #2: sodium periodate In 1,4-dioxane; water at 20℃; for 72h;	81.3%

sodium periodate (7790-28-5) + mannitol (69-65-8) + 2,2-dimethoxy-propane (77-76-9) → 2,3-isopropylidene-glyceraldehyde (15186-48-8)

Conditions	Yield
Stage #1: mannitol; 2,2-dimethoxy-propane With tin(ll) chloride Stage #2: sodium periodate	76%

sodium periodate (7790-28-5) + tris(1,10-phenanthroline)cobalt(III) chloride + water (7732-18-5) → tris(1,10-phenanthroline)cobalt(III) periodate dihydrate

Conditions	Yield
In water aq. solns. of cobalt complex and sodium salt mixed; solid filtered off, washed with cold water, alcohol, dried in air; elem.anal.;	75%

sodium periodate (7790-28-5) + C4H4O2(CH3)2C6H8NN(CH3)2 (99474-79-0) + 5-Iodo-2-trimethylstannylpent-1-ene (99474-78-9) → C4H4O2(CH3)2C6H7(O)((CH2)3C(Sn(CH3)3)CH2) (99474-81-4)

Conditions	Yield
With lithium diisopropyl amide In tetrahydrofuran alkylation at room temp. for 8 h followed by addn. of 2 equiv. of NaIO4at pH 7 at room temp. (12 h);	70%

sodium periodate (7790-28-5) + sodium molybdate dihydrate (7631-95-0) + choline chloride (67-48-1) + water (7732-18-5) → 2[(CH3)3NC2H4OH](1+)*H3O(1+)*2Na(1+)*7H2O*IMo6O24(5-)=[(CH3)3NC2H4OH]2(H3O)[Na2(H2O)6][IMo6O24]*H2O

Conditions	Yield
With urea In acetic acid Mo compd. added to a eutectic mixt. of N compds., stirred, I compd. added, solvents added, stirred for 4 h at room temp.; filtered, kept at room temp. for 3 d, crysts. filtered, washed (abs. alcohol), dried (vac., 80°C, 0.5 h); elem. anal., powder XRD, TGA;	64%

sodium periodate (7790-28-5) + acetylferrocene (1271-55-2) → ferrocenecarboxylic acid (1271-42-7)

Conditions	Yield
In water all manipulations under inert atm.; aq. soln. of Na salt added to solid complex, stirred for 8 h at room temp.; filtered, washed with water, filtrate acified with glacial AcOH, pptd. with Na2S2O5, dried;	63%

sodium periodate (7790-28-5) + [iridium(I)(1,5-cyclooctadiene){(MeIm)2CHCOO}] + water (7732-18-5) → [iridium(III)(hydroxo)(1,5-cyclooctadiene){(MeIm)2CHCOO}](IO3)

Conditions	Yield
for 0.25h; Schlenk technique; Inert atmosphere;	63%

sodium periodate (7790-28-5) + 1,10-Phenanthroline (66-71-7) + potassium osmate (77347-87-6) → [OsO2(1,10-phenanthroline)(IO3(OH)3)]

Conditions	Yield
In water; acetone addn. of phenanthroline to soln. of Os-compd. in 50% Me2CO, stirring, addn. of aq. NaIO4 (pptn.); elem. anal.;	57%

sodium periodate (7790-28-5) + ((CHC4N(CH3)(CH2CH2CO(O)CH3))2CHC4NH(CH3)CHC4N(CHCH3)(CH3)(CH2C(O)N(CH3)2))Zn → ((CHC4N(CH3)(CH2CH2C(O)OCH3))2CHC4NH(CH3)CHC4N(O)(CH3)(CH2C(O)N(CH3)2))Zn (144320-57-0)

Conditions	Yield
With K2CO3; KMnO4 In water; tert-butyl alcohol room temp., 30 min; flash chromy. (silica gel, CH2Cl2/methyl acetate (6+1)), crystd. (CHCl3/n-hexane);	56%

sodium periodate (7790-28-5) + 1-methyl-6-vinyl-benzimidazole (813449-02-4) → 1-methyl-1H-benzo[d]imidazole-6-carbaldehyde (181867-19-6)

Conditions	Yield
With osmium(VIII) oxide In 1,4-dioxane; water at 20℃; for 3h;	55%

sodium periodate (7790-28-5) + sodium carbonate (497-19-8) + molybdenum(VI) oxide → Na5(IMo6O24)*16H2O + carbon dioxide (124-38-9)

Conditions	Yield
In water addn. of MoO3 and Na2CO3 to slurry of NaIO4, boiling, filtration off of traces unreacted MoO3, crystn. on slow evapn.; recrystn. (hot water); elem. anal.;	A 55% B n/a

sodium periodate (7790-28-5) + betulonic acid (4481-62-3) → 3,20-dioxo-29-norlupan-28-oic acid

Conditions	Yield
Stage #1: betulonic acid With osmium(VIII) oxide In 1,4-dioxane; water at 20℃; for 1h; Stage #2: sodium periodate In 1,4-dioxane; water at 20℃; for 72h;	50.3%

ruthenium(IV) oxide + sodium periodate (7790-28-5) → [RuO2(2,2'-bipyridyl)(IO3(OH)3)]

Conditions	Yield
With water; 2,2'-bipyridyl In water; acetone addn. of NaIO4 to aq. suspn. of RuO2, addn. to 2,2'-bipyridine (in 50% aq. Me2CO), stirring (room temp.; pptn.); elem. anal.;	48%

sodium periodate (7790-28-5) + iodine pentoxide (12029-98-0) + copper(II) choride dihydrate + ethanol (64-17-5) + 1,4-diazabicyclo[2.2.2]octane hexahydrate → (N,N'-diethyl-1,4-diazabicyclo-[2.2.2]octane)2[Cu4I8]

Conditions	Yield
With hydrogenchloride; sodium carbonate In water at 180℃; for 120h; Autoclave; High pressure;	48%

sodium periodate (7790-28-5) + potassium osmate (77347-87-6) → [OsO2(2,2'-bipyridyl)(IO3(OH)3)] * 1.5H2O

Conditions	Yield
With 2,2'-bipyridyl In water; acetone addn. of bipy to soln. of Os-compd. in 50% Me2CO, stirring, addn. of aq. NaIO4 (pptn.); elem. anal.;	40%

sodium periodate (7790-28-5) + ruthenium(III) chloride trihydrate + tetrapropylammonium hydroxide (4499-86-9) → tetrapropylammonium perruthennate (114615-82-6)

Conditions	Yield
Stage #1: tetrapropylammonium hydroxide With sodium hydroxide In water Stage #2: sodium periodate; ruthenium(III) chloride trihydrate In water at 20℃; for 16h;	33%

ruthenium(IV) oxide + sodium periodate (7790-28-5) + orthotelluric acid (7803-68-1) → [RuO2(2,2'-bipyridyl)(TeO2(OH)4)] (172267-60-6)

Conditions	Yield
With water; 2,2'-bipyridyl In water; acetone addn. of NaIO4 to aq. suspn. of RuO2, addn. to mixt. of 2,2'-bipyridineand Te(OH)6 (in 50% aq. Me2CO), stirring (room temp., 5 min; pptn.); elem. anal.;	29%

sodium periodate (7790-28-5) + di(pyridin-2-yl)amine (1202-34-2) + potassium osmate (77347-87-6) → [OsO2(2,2'-dipyridylamine)(IO3(OH)3)]

Conditions	Yield
In water; acetone addn. of ligand to soln. of Os-compd. in 50% Me2CO, stirring, addn. of aq. NaIO4 (pptn.); elem. anal.;	28%

sodium periodate (7790-28-5) + λ-α,β-bidentate Cr(H2O)4ADPαS + aniline hydrochloride (142-04-1) → Cr(H2O)4PPS

Conditions	Yield
With mercaptoethyl alcohol oxidn. with NaIO4 at pH 6 for 5 min, then addn. of mercaptoethanol for 5 min., then β-elimination with aniline hydrochloride soln. (pH 5); purifn. on a Dowex-50 ( H(1+)) column by using water as eluant;	20%

Upstream product

• 7782-50-5 chlorine 
• 1310-73-2 sodium hydroxide 
• 7790-21-8 potassium metaperiodate 
• 13444-71-8 periodic acid 
• 7681-82-5 sodium iodide 
• 7553-56-2 iodine 
• 7757-82-6 sodium sulfate 

Downstream Products

• 10028-15-6 ozone 
• 14900-04-0 triiodide^(1-) 
• 7553-56-2 iodine 
• 20427-56-9 ruthenium tetroxide 
• 114615-82-6 tetrapropylammonium perruthennate 
• 6060-06-6 platanic acid 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 1082750-53-5 (R)-2-((tert-butoxycarbonyl)amino)-4-(4-(trifluoromethyl)phenyl)butanoic acid 
• 192943-54-7 10-((tert-butyldiphenylsilyl)oxy)decanal 
• 33550-56-0 (iodomethyl)(triphenyl)stannane 
• 99474-81-4 C₄H₄O₂(CH₃)2C₆H₇(O)((CH₂)3C(Sn(CH₃)3)CH₂) 
• 99474-80-3 C₄H₄O₂(CH₃)2C₆H₇(O)((CH₂)2C(Sn(CH₃)3)CH₂) 
• 86012-02-4 (C₆H₅)3SnCH₂CH₂S(O)C₆H₄CH₃ 
• 22207-96-1 potassium perbromate 

Relevant articles and documents

Regeneration of Aqueous Periodate Solutions by Ozone Treatment: A Sustainable Approach for Dialdehyde Cellulose Production

A method for easy and fast regeneration of aqueous periodate solutions from dialdehyde cellulose (DAC) production by ozone treatment is presented, along with a direct and reliable simultaneous quantification of iodate and periodate by reversed-phase HPLC. The influence of iodate and ozone concentration, solution pH, and reaction time on the regeneration efficiency was studied, as well as the reaction kinetics. Regeneration of spent periodate solutions by ozone was successfully performed in alkaline medium, which favors the formation of free .OH radicals, as supported by the addition of radical scavengers and quantum mechanical calculations. At pH 13 and an ozone concentration of approximately 150 mg L-1, periodate was completely regenerated from a 100 mm solution of iodate within 1 h at room temperature. A cyclic process of cellulose oxidation and subsequent regeneration of spent periodate with 90 % efficiency has been developed. So far, commercial applications of DAC have been hampered by difficulties in reusing the costly periodate. This work overcomes this hurdle and presents a highly efficient, clean, and low-cost protocol for the preparation of DAC with integrated periodate recycling, with the possibility of scaling the process up.

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