Synlett p. 591 - 592 (1997)
Update date:2022-08-10
Topics:
Katsuyama, Isamu
Funabiki, Kazumasa
Matsui, Masaki
Muramatsu, Hiroshige
Shibata, Katsuyoshi
The treatment of α-alkoxycarbonyl-α,β-unsaturated trifluoromethyl ketones 1 with β-aminocrotonates 2 affords 2-methyl-6-trifluoromethyl-1,4-dihydropyridines 3, which undergo dehydrofluorination using DBU/piperazine, giving moderate to high yields of 2-difluoromethyl-6-methylpyridines 4.
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