Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R)- formoterol

Article abstract of DOI:10.1016/S0040-4039(98)00137-3

Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone I. Readily accessible (1R, 2S) 1-amino- 2-tetralol (B-H) derived oxazaborolidine catalyst (6b) proves to be the most effective and practical catalyst in the reduction of bromo-ketone 1 (96% ee).