Conformational toolbox of oxazaborolidine catalysts in the enantioselective reduction of α-bromo-ketone for the synthesis of (R,R)- formoterol

DOI: 10.1016/S0040-4039(98)00137-3

Source and publish data:

Tetrahedron Letters p. 1705 - 1708 (1998)

Update date:2022-08-11

Topics:

Authors:

Hett, Robert

Senanayake, Chris H.

Wald, Stephen A.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(98)00137-3

Several conformationally constrained oxazaborolidine catalysts have been evaluated in the reduction of ketone I. Readily accessible (1R, 2S) 1-amino- 2-tetralol (B-H) derived oxazaborolidine catalyst (6b) proves to be the most effective and practical catalyst in the reduction of bromo-ketone 1 (96% ee).

Full text of DOI:10.1016/S0040-4039(98)00137-3

Products guided by the article

Product name:(R)-1-(4-Benzyloxy-3-nitrophenyl)-2-bromoethanol

Cas No:188690-82-6

R&D Labs maybe for 188690-82-6

Shanghai Harvest Chemical Ind. Co., Ltd.

Contact:021-51385350

Address:ROOM 806-807, AI LI CHEN BUILDING, No.333 JINGXIANG ROAD, PUDONG DISTRICT, 201206, SHANGHAI
Suzhou CarbonWell Pharma-Tech Co., Ltd

Contact:Tel: + 86 (0)512-8898-1216; + 86-18606258602

Address:2358 Changan Road, Wujiang Scientific Innovation Park, Wujiang, Jiangsu Province, P. R. China 215200
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Shanghai Sinofluoro Scientific Co., Ltd

Contact:+86-21-64279360

Address:Room 1006,Building 3,#58 East Xinjian Road, Shanghai ,201100,China,
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China

Relevant to this article

Green and efficient protocol for N-alkylation of benzotriazole using basic ionic liquid [Bmim]OH as catalyst under solvent-free conditions

Doi:10.1080/00397910903277888
(2010)
Diethyl Oxomalonate. An Improved Synthesis

Doi:10.1021/jo00325a039
(1981)
The application of N,N′-dibromo-N,N′-1,2-ethanediylbis (p-toluenesulphonamide) as a powerful reagent for deoximation of various oximes

Doi:10.1016/S0040-4039(01)00897-8
(2001)
Enzyme-catalyzed enantioselective diaryl ketone reductions

Doi:10.1021/ol0627909
(2007)
Nitration of aromatic compounds catalyzed by divanadium-substituted molybdophosphoric acid, H₅[PMo₁₀V₂O ₄₀]

Doi:10.1007/s00706-007-0593-6
(2007)
Stereoselective cyclopropanation of enones with ethyl dimethylsulfonium acetate bromide in the presence of DBU

Doi:10.1016/S0040-4039(97)00265-7
(1997)

Article Doi