Bioorganic and Medicinal Chemistry Letters p. 1585 - 1588 (1998)
Update date:2022-08-28
Topics:
Wang, Peiyuan
Schinazi, Raymond F.
Chu, Chung K.
Asymmetric synthesis of L-carbocyclic 2',3'-didehydro-2',3'- dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that L-carbocyclic 2',3'-didehydro- 2',3'-dideoxyadenosine exhibited moderately potent anti-HIV (EC50 = 2.4 μM) activity in human PBM cells without cytotoxicity up to 100 μM.
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