Tetrahedron p. 3839 - 3848 (1989)
Update date:2022-08-16
Topics:
Kocienski, Philip J.
Love, Christopher J.
Whitby, Richard J.
Costello, Gerard
Roberts, David A.
Total syntheses of the spasmogenic diterpenoid zoapatanol and a demethyl analogue of the potent antigestational agent ORF 13811 are reported.A Ni0-catalysed coupling of MeMgBr with a dihydrofuran, and a carbo- or hydro-magnesiation of an acetylene were used to construct the trisubstituted alkenes in the key intermediates with high stereoselectivity.
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Doi:10.1002/ejoc.201402977
(2014)Doi:10.1021/acs.joc.8b00952
(2018)Doi:10.1038/nm.2436
(2011)Doi:10.1055/s-2007-967998
(2007)Doi:10.1016/S0040-4039(00)99734-X
(1970)Doi:10.1002/chem.200902951
(2010)
