Tetrahedron p. 3839 - 3848 (1989)
Update date:2022-08-16
Topics:
Kocienski, Philip J.
Love, Christopher J.
Whitby, Richard J.
Costello, Gerard
Roberts, David A.
Total syntheses of the spasmogenic diterpenoid zoapatanol and a demethyl analogue of the potent antigestational agent ORF 13811 are reported.A Ni0-catalysed coupling of MeMgBr with a dihydrofuran, and a carbo- or hydro-magnesiation of an acetylene were used to construct the trisubstituted alkenes in the key intermediates with high stereoselectivity.
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(2010)
