A general and efficient five-step one-pot procedure leading to nitrogen-bridgehead heterocycles containing an imidazole ring

Article abstract of DOI:10.1021/ol070263z

A very simple annulation reaction was designed, allowing an imidazole moiety to be fused onto a range of pyridine-based derivatives. The methodology consists of an activation step via the formation of a pyridinium salt to increase the electrophilicity of