A novel cyclization reaction of a C-6 substituted uridine analog: An entry to 5,6-dialkylated uridine derivatives

DOI: 10.1016/S0040-4039(01)93409-4

Source and publish data:

Tetrahedron Letters p. 7005 - 7008 (1989)

Update date:2022-08-30

Topics:

Authors:

Wang Wang

Kagel Kagel

Rao Rao

Mertes Mertes

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Article abstract of DOI:10.1016/S0040-4039(01)93409-4

5,6-Dialkylated uridine derivatives were conveniently synthesized in 5 steps starting from 2',3'-O-isopropylideneuridine (1) in a 43% overall yield. The key reaction is a novel acid catalyzed cyclization reaction of 6-(4-butanal)-2',3'-O-isopropylideneuridine.

Full text of DOI:10.1016/S0040-4039(01)93409-4

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