Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129

DOI: 10.1016/S0960-894X(99)00327-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2037 - 2038 (1999)

Update date:2022-08-10

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Authors:

Mitsuya, Morihiro

Kawakami, Kumiko

Ogino, Yoshio

Miura, Keiko

Mase, Toshiaki

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Article abstract of DOI:10.1016/S0960-894X(99)00327-3

A diastereoselective synthesis of J-104129 (1) was developed. A key step of this synthesis was Michael addition of enolate generated from cis-chiral dioxolane 2 to cyclopentenone, followed by hydrogenolysis of the resultant enol triflate 4. A mixture of c

Full text of DOI:10.1016/S0960-894X(99)00327-3

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