Tetrahedron Asymmetry p. 1789 - 1796 (2000)
Update date:2022-08-17
Topics:
Basso, Alessandra
Braiuca, Paolo
De Martin, Luigi
Ebert, Cynthia
Gardossi, Lucia
Linda, Paolo
Penicillin G acylase in organic solvents catalyses specifically the acylation of the L-enantiomers of methyl esters of phenylglycine and 4- hydroxyphenylglycine. Hydrolytic reactions are prevented by controlling the water activity of the system and no excess of acylating agent is required. The process leads to the facile isolation of the enantiomerically pure D- enantiomer, which is of practical use for the preparation of β-lactam antibiotics. Electrospray mass spectroscopy has been applied to the study of the enantioselectivity of the enzyme. (C) 2000 Elsevier Science Ltd.
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