REVISED STRUCTURES FOR GUAIANOLIDE α-METHYLENEBUTYROLACTONES FROM FEVERFEW

Article abstract of DOI:10.1016/0031-9422(89)80150-5

The structures of two series of guaianolides present in feverfew, Tanacetum parthenium, are established as tanaparthin-α-peroxide, canin and seco-tanapartholide-A and the corresponding 'β'-series <β-peroxide, artecanin and the seco-B derivative> using a combination of spectroscopic and X-ray crystallographic analyses and chemical transformations.Key Word Index - Tanacetum parthenium; Compositae; feverfew; sesquiterpene lactones; parthenolide; guaianolides; migraine.