New and effective synthesis of unsymmetrical α-ureidoalkylphosphonates

Article abstract of DOI:10.1080/10426500008043670

An efficient synthesis of substituted α-ureidoalkylphosphonates 3 was reported. The method involves the conversion of α-aminoalkylphosphonates 1 to α-isocyanatoalkylphosphonates 2 by treating with triphosgene and followed by addition of substituted amine to 2. A new kind of cyclic α-ureidoalkylphosphonates 5 was also obtained by treating 2 with ?-aminobenzoic acid, followed by intramolecular cyclization of intermediate 4.

Full text of DOI:10.1080/10426500008043670

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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NEW AND EFFECTIVE
SYNTHESIS OF UNSYMMETRICAL
α-UREIDOALKYLPHOSPHONATES
a
a
a
Zai-Guo Li , Qing-Min Wang , Run-Qiu Huang
,
a
a
Jun-Ran Cheng & Jun-An Ma
a
Institute and State Key Laboratory of Elemento-
Organic Chemistry , Tianjin, 300071, People's
Republic of China
Published online: 04 Oct 2006.
To cite this article: Zai-Guo Li , Qing-Min Wang , Run-Qiu Huang , Jun-Ran Cheng
&
Jun-An Ma (2000) NEW AND EFFECTIVE SYNTHESIS OF UNSYMMETRICAL α-
UREIDOALKYLPHOSPHONATES, Phosphorus, Sulfur, and Silicon and the Related
Elements, 160:1, 51-59, DOI: 10.1080/10426500008043670
To link to this article: http://dx.doi.org/10.1080/10426500008043670
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