Extension of the Eschweiler-Clarke procedure to the N-alkylation of amides

DOI: 10.1016/S0040-4039(00)76894-8

Source and publish data:

Tetrahedron Letters p. 3313 - 3314 (1994)

Update date:2022-08-16

Topics:

Authors:

Fache, Fabienne

Jacquot, Laurent

Lemaire, Marc

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)76894-8

The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na₂SO₄ as catalyst. Good isolated yields are obtained (81% to 98%).

Full text of DOI:10.1016/S0040-4039(00)76894-8

Products guided by the article

Product name:N-Octyl pyrrolidone

Cas No:2687-94-7

R&D Labs maybe for 2687-94-7

Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Hefei Highzone Fine Chemical S&T CO.,LTD

Contact:86-0551-63663560

Address:room 1801 NO. 24 Shuguang RD.
Tai zhou world Pharm & Chem Co., Ltd

Contact:+86-576-85301198

Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
NINGBO YINZHOU PRECISE COLOR CO.,LTD.

Contact:86-574-88139809 86-574-83033159

Address:Qiming Road,Yinzhou,Ningbo,China
Shanghai Yurui Biotechnology(Anyang) Pharmaceutical Co., Ltd

Contact:+86-0372-3662335 +86-0372-3661988

Address:hanling industrial park anyang

Relevant to this article

Ytterbium perfluorooctanesulfonates catalyzed synthesis of benzimidazole derivatives in fluorous solvents

Doi:10.1016/j.jfluchem.2007.01.009
(2007)
Enantioselective Allylation of Aldehydes with (Dialkoxyallyl)chromium(III) Complexes

Doi:10.1021/jo970069y
(1997)
Isostearyl Mixed Anhydrides for the Preparation of N-Methylated Peptides Using C-Terminally Unprotected N-Methylamino Acids

Doi:10.1021/acs.orglett.0c02984
(2020)
Diisopinocampheylchloroborane, a Remarkably Efficient Chiral Reducing Agent for Aromatic Prochiral Ketones

Doi:10.1021/jo00225a109
(1985)
A NEW SYNTHESIS OF ATANINE, KHAPLOFOLINE AND THEIR ANALOGUES

Doi:10.1016/S0040-4039(00)86996-8
(1982)
β-Diketone synthesis by reaction of α-haloketones with acid chlorides or acid anhydrides promoted by samarium triiodide

Doi:10.1080/00397919608005226
(1996)

Article Doi