Tetrahedron Letters p. 3313 - 3314 (1994)
Update date:2022-08-16
Topics:
Fache, Fabienne
Jacquot, Laurent
Lemaire, Marc
The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na2SO4 as catalyst. Good isolated yields are obtained (81% to 98%).
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