Extension of the Eschweiler-Clarke procedure to the N-alkylation of amides

DOI: 10.1016/S0040-4039(00)76894-8

Source and publish data:

Tetrahedron Letters p. 3313 - 3314 (1994)

Update date:2022-08-16

Topics:

Authors:

Fache, Fabienne

Jacquot, Laurent

Lemaire, Marc

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Article abstract of DOI:10.1016/S0040-4039(00)76894-8

The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na₂SO₄ as catalyst. Good isolated yields are obtained (81% to 98%).

Full text of DOI:10.1016/S0040-4039(00)76894-8

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