Journal of Natural Products p. 1132 - 1135 (2003)
Update date:2022-08-16
Topics:
Li, Xing-Cong
Jacob, Melissa R.
ElSohly, Hala N.
Nagle, Dale G.
Smillie, Troy J.
Walker, Larry A.
Clark, Alice M.
Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
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