2777-64-2Relevant academic research and scientific papers
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia
Li, Xing-Cong,Jacob, Melissa R.,ElSohly, Hala N.,Nagle, Dale G.,Smillie, Troy J.,Walker, Larry A.,Clark, Alice M.
, p. 1132 - 1135 (2003)
Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.
