Dyes and Pigments p. 1 - 6 (2017)
Update date:2022-08-22
Topics:
Wang, Ming-Qi
Wu, Yuan
Wang, Zi-Yu
Chen, Qiu-Yun
Xiao, Fu-Yan
Jiang, Yu-Chi
Sang, Amy
Searching for specific G-quadruplex DNA probes is important for study of the function of G-rich gene sequence, as well as design of novel effective anticancer drugs. In this paper, a novel bis-amine-substituted styrylquinolinium dye (BSAQ) was designed and synthesized to enhance the performance for the application as a G-quadruplex DNA probe. The studies on BSAQ with different DNA forms showed that it could be used as a colorimetric and red-emitting ?uorescent probe for G-quadruplex DNA. The limits of detection of BASQ with various G-quadruplex DNAs were found to below 1 nM. CD spectroscopy analysis revealed that BSAQ did not induce the G-rich sequence folding into G-quadruplex structure. These results of this study gave some crucial factors on developing of effective probes for G-quadrupex DNA applications.
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Doi:10.1016/j.ejmech.2017.11.067
(2018)Doi:10.1021/jp991183i
(1999)Doi:10.1007/BF01152239
()Doi:10.1039/c3ra42570c
(2013)Doi:10.1021/ja00387a006
(1982)Doi:10.1002/asia.201800681
(2018)