Synthesis and antiviral activity of C-5 substituted β-D- and β-l-D4T analogues

Article abstract of DOI:10.1080/15257770008033853

A series of β-D-2',3'-didehydro-2',3'-dideoxy-nucleosides bearing a tether attached at the C-5 position and their β-L-counterparts was synthesized. Their inhibitory activities against human immunodeficiency vires (HIV) were investigated and compared to establish relationship(s) between compound structure and their antiviral activity. No significant activity was observed for β-D- and β-L-modified nucleosides respectively 7a-c and 14a-c, but 7d and 14d exhibited a weak activity against HIV-1.

Full text of DOI:10.1080/15257770008033853

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Nucleosides, Nucleotides and Nucleic
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Synthesis and Antiviral Activity of C-5
Substituted β-D- and β-L-D4T Analogues
Z. Delbederi a , C. Fossey a , G. Fontaine a , S. Benzaria a , D.
Gavriliu a , A. Ciurea a , B. Lelong a , D. Ladurée a , A. M. Aubertin b
& A. Kirn b
a Centre d'Etudes et de Recherche sur le Médicament de Normandie
U. F. R. des Sciences Pharmaceutiques , 5, Rue Vaubénard, 14032,
Caen Cedex, France
b I. N. S. E. R. M., 3, Rue Koeberlé , 67000, Strasbourg, France
Published online: 24 Sep 2006.
To cite this article: Z. Delbederi , C. Fossey , G. Fontaine , S. Benzaria , D. Gavriliu , A. Ciurea ,
B. Lelong , D. Ladurée , A. M. Aubertin & A. Kirn (2000) Synthesis and Antiviral Activity of C-5
Substituted β-D- and β-L-D4T Analogues, Nucleosides, Nucleotides and Nucleic Acids, 19:9, 1441-1461,
DOI: 10.1080/15257770008033853
To link to this article: http://dx.doi.org/10.1080/15257770008033853
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