Journal of the Chemical Society. Perkin transactions I p. 408 - 412 (1981)
Update date:2022-08-11
Topics:
Drewes, Siegfried E.
Pitchford, Andrew T.
Reaction of 2,6-bis(bromomethyl)pyridine with the naturally-occuring C10 necic acid, retronecic acid, results in the formation of a new semi-synthetic cyclic diester alkaloid, pyridine-retronecate.This product is an analogue of a pyrrolizidine alkaloid and retains those characteristics normally held responsible for the toxity of this class of alkaloids.Biological tests carried out on mice injected with retrorsine and with the synthetic analogue suggest that the cytotoxic effects are similar.
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