Chemical and Pharmaceutical Bulletin p. 340 - 343 (1995)
Update date:2022-08-18
Topics:
Onishi
Machida
Nagai
The mixture of 2'-O-(4-carboxybutyryl)-5-fluorouridine (2'-glu-FUR) and 3'-O-(4-carboxybutyryl)-5-fluorouridine (3'-glu-FUR), named (glu-FUR(I)), and 5'-O-(4-carboxybutyryl)-5-fluorouridine (5'-glu-FUR), named glu-FUR(II), were easily obtained from the reaction of 5-fluorouridine (FUR) with glutaric anhydride. In addition, the chitosan-glu-FUR(I) conjugate and the chitosan-glu-FUR(II) conjugate were prepared. The obtained compounds were investigated regarding their in vitro characteristics. Equilibrium between 2'-glu-FUR and 3'-glu-FUR was suggested to be attained quickly in a 1/15 M phosphate buffer of pH 7.4. Glu-FUR(II) was found to be introduced into chitosan more easily than glu-FUR(I). For every compound, chemical hydrolysis was accelerated at weakly basic pH and a gradual regeneration of FUR was observed at physiological pH.
View MoreContact:86-571-85586718
Address:join hands science park,NO.4028 nanhuan road,hanghzou ,zhejiang,china
SJZ Chenghui Chemical Co., Ltd.
Contact:86-311-87713916
Address:no.368 youyi north avenue
TAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road,Taixing City ,Jiangsu , China
Tianjin SPHINX SCIENTIFIC LAB.
Contact:+86-022-66211289
Address:Tianda high-tech Park. No.80,the 4th Avenue
Tianjin Anda North Industrial & Business Co.Ltd.
Contact:86-22-24999306
Address:No.11 Erwei Road,Dongli Development Area,Tianjin,China
Doi:10.1021/jo00164a034
(1983)Doi:10.1039/jr9590003228
(1959)Doi:10.1016/j.tetlet.2013.08.012
(2013)Doi:10.1002/cssc.201500025
(2015)Doi:10.1021/ja00487a043
(1978)Doi:10.1039/b103586j
(2001)