Optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon

Article abstract of DOI:10.1016/S0957-4166(97)00473-4

Enantioselective esterification of α-substituted propargylic alcohols was found to proceed very smoothly in the presence of a catalytic amount of lipase (Nobozym 435) to yield the corresponding (R)-alcohols and (S)-acetates with high enantiomeric excess. Further, the preparation of optically active propargylic and allylic alcohols with a difluoromethyl group at the terminal carbon is described.