Molecules p. 8614 - 8628 (2011)
Update date:2022-08-17
Topics:
Pertino, Mariano Walter
Theoduloz, Cristina
Palenzuela, Jose Antonio
Del Mar Afonso, Maria
Yesilada, Erdem
Monsalve, Francisco
Gonzalez, Paulo
Droguett, Daniel
Schmeda-Hirschmann, Guillermo
New diterpenylquinones, combining a diterpene diacid and a naphthoquinone, were prepared from junicedric acid and lapachol. The new derivatives were assessed as gastroprotective agents by the HCl-EtOH-induced gastric lesions model in mice as well as for basal cytotoxicity on the following human cell lines: Normal lung fibroblasts (MRC-5), gastric epithelial adenocarcinoma (AGS), and hepatocellular carcinoma (Hep G2). Several of the new compounds were significantly active as antiulcer agents and showed selective cytotoxicity against AGS cells.
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