An efficient resolution of (±)-S-methyl-S-phenylsulfoximine with (±)-10-camphorsulfonic acid by the method of half-quantities

Article abstract of DOI:10.1016/S0957-4166(97)00046-3

Racemic S-methyl-S-phenylsulfoximine (±)-1 can be resolved with only 0.6 equivalents of (+)-camphorsulfonic acid by avoiding any recrystallization to give (+)-1 of ≤99% ee in 80% yield and (-)-1 of 97-99% ee in 74% yield. This procedure, which is based on