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ChemComm
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DOI: 10.1039/C7CC03024J
Journal Name
COMMUNICATION
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catalysts inside the flow reactor the initial rate constant was
about 7 times higher compared to CCMVAu7B on glass with
same amount of Au particles, which can be attributed to a
higher surface to volume ratio in the flow reactor. It should be
noted that the VLPs in the flow reactor are highly stable, no
particle loss was observed after reaction, which was confirmed
by AFM analysis and UV-vis spectroscopy (Figure S2.7).
Table 1. Reduction rates obtained for continuous flow reactions using a microreactor
coated with CCMVAu7B.
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running time [h]
6
kinnitial [s-1]
0.74·10-2±2.26·10-4
koverall [s-1]
5.50·10-3±5.30·10-4
12
18
24
30
1.00·10-2±6.80·10-5
0.71·10-2±4.96·10-5
1.10·10-2±3.08·10-4
1.24·10-2±6.85·10-4
2.63·10-3±1.21·10-4
4.01·10-3±1.92·10-4
4.67·10-3±5.00·10-4
2.37·10-3±5.20·10-4
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2586-2605.
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In conclusion, we have successfully fabricated a microfluidic
reactor by immobilizing catalytic VLPs on the inner surface.
The VLPs, based on CCMV protein cages with gold
nanoparticles encapsulated inside, were shown to be
efficiently immobilized with high stability. A model reduction
reaction was carried out successfully in the reactor, which was
used 5 days in continuous flow without loss of conversion,
highlighting the stability of this virus-like particle based flow
reactor. The presented approach is not limited to specific
catalysts, and is adaptable to other (bio) organic
nanocontainers with a variety of functional nanoparticles
encapsulated within. It is anticipated that the adoption of this
strategy can move forward the industrial application of
catalytic virus-like nanoparticles.
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