Highly Diastereoselective Addition of Organometallics to Novel Chiral α-Ketoamides of (S)-2-Methoxymethylindoline

Article abstract of DOI:10.1016/0957-4166(95)00115-6

The stereocontrolled nucleophilic addition of organometallics to novel chiral α-ketoamides which were synthesized from (S)-2-methoxymethylindoline as a chiral auxiliary was carried out to obtain α-hydroxyamides with extremely high diastereoselectivities (up to dr <*> 99:1).