Biocatalyst-Mediated Efficient Preparation of Highly Enantiomerically Enriched (R)-5-Hexanolide

DOI: 10.1055/s-1997-972

Source and publish data:

Synlett p. 983 - 985 (1997)

Update date:2022-08-18

Topics:

Authors:

Sugai, Takeshi

Hamada, Keiji

Akeboshi, Tomohiro

Ikeda, Hajime

Ohta, Hiromichi

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Article abstract of DOI:10.1055/s-1997-972

Biocatalyst-mediated efficient preparation of highly enantiomerically enriched (R)-5-hexanolide (1) is described. The enantioselective reduction of 5-oxohexanoic acid with Yamadazyma farinosa IFO 10896 and the subseqent lipase-catalyzed kinetic resolution gave (R)-1 in 62% yield with 99.7% e.e.

Full text of DOI:10.1055/s-1997-972

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