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18162-48-6

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Basic Information
CAS No.: 18162-48-6
Name: Silane,chloro(1,1-dimethylethyl)dimethyl-
Molecular Structure:
Molecular Structure of 18162-48-6 (Silane,chloro(1,1-dimethylethyl)dimethyl-)
Formula: C6H15ClSi
Molecular Weight: 150.72
Synonyms: Silane,chloro-tert-butyldimethyl- (8CI);(1,1-Dimethylethyl)dimethylsilyl chloride;Chloro-tert-butyldimethylsilane;Dimethyl(1,1-dimethylethyl)chlorosilane;Dimethyl-tert-butylsilyl chloride;TBDMS chloride;TBDMS-Cl;t-Butyldimethylchlorosilane;tert-Butyl(dimethyl)silane chloride;tert-Butyldimethylchlorosilane;Tert-butyldimethylsilyl chloride ( TBMS );T-Butyldimethylsilyl chloride;tert-Butyldimethylsilyl chloride;
EINECS: 242-042-4
Density: 0.862 g/cm3
Melting Point: 86-89 °C
Boiling Point: 125 °C at 760 mmHg
Flash Point: 22.8 °C
Solubility: Soluble in chloroform and ethyl acetate. Insoluble in water.
Appearance: White solid
Hazard Symbols: CorrosiveC,FlammableF,ToxicT
Risk Codes: 22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25
Safety: 26-36/37/39-46-62-45-25-16-28-27-33-29-53
Transport Information: UN 2925 4.1/PG 2
PSA: 0.00000
LogP: 3.23040
Related products
Synthetic route
29681-57-0

tert-butyldimethylsilane

563-47-3

3-Chloro-2-methylpropene

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
palladium diacetate99.8%
72726-46-6

tert-butyl(dimethyl)(phenylseleno)silane

A

1666-13-3

diphenyl diselenide

B

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With chlorine In tetrachloromethaneA 96%
B 93%
75-44-5

phosgene

75-77-4

chloro-trimethyl-silane

18173-64-3

tert-butyldimethylsilanol

107-06-2

1,2-dichloro-ethane

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide96%
...Expand
75-44-5

phosgene

75-77-4

chloro-trimethyl-silane

18173-64-3

tert-butyldimethylsilanol

107-06-2

1,2-dichloro-ethane

93-61-8

N-methyl-N-phenylformamide

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
92%
...Expand
29681-57-0

tert-butyldimethylsilane

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With hexachloroethane; palladium dichloride In tetrahydrofuran at 20℃; for 2h;89%
With tetrabutylammonium perchlorate; copper(l) chloride In 1,2-dimethoxyethane electrochemical reaction;83%
With copper(l) iodide; copper dichloride In tetrahydrofuran; diethyl ether at 20℃; for 60h;73%
18159-55-2

tri-t-butylsilane

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With hydrogenchloride; palladium on activated charcoal In hexane at 25℃; for 2h;87%
507-20-0

tertiary butyl chloride

75-78-5

dimethylsilicon dichloride

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With magnesium In tetrahydrofuran; hexane78%
With copper(l) cyanide; magnesium In tetrahydrofuran for 2h; Heating;74%
66548-21-8

di(methyl)tert-butyl(methoxy)silane

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With hydrogenchloride In water at 20℃; for 10h;78%
With hydrogenchloride In hexane at 0℃; for 2h;71%
With hydrogenchloride In water at 20℃; for 5 - 10h; Product distribution / selectivity;60%
594-19-4

tert.-butyl lithium

75-78-5

dimethylsilicon dichloride

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In pentane for 2h; Heating;61%
75-78-5

dimethylsilicon dichloride

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With t-C4H9Li In not given58%
With tert.-butyl lithium In not given58%
66348-17-2

bis(trifluoromethyl)germanium chloride

80594-86-1

1,3-di-tert-butyl-1,1,3,3-tetramethyldisilatellurane

A

112438-43-4

bistris(trifluoromethyl)germyl telluride

B

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
Ar atmosphere, heating (80°C, 2 d); protection against light; fractional sublimation; elem. anal.;A 52%
B n/a
...Expand
18173-64-3

tert-butyldimethylsilanol

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With thionyl chloride In chloroform for 0.5h;39%
With hydrogenchloride In hexane at 0℃; for 2h;98 % Chromat.
2357-76-8

tert-butyldimethylfluorosilane

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
With chloro-trimethyl-silane; aluminium trichloride
96760-01-9

1-(tert-butyldimethylsilyloxy)-1-isopropoxycyclopropane

A

75-29-6

isopropyl chloride

B

18162-48-6

tert-butyldimethylsilyl chloride

C

isopropyl 3-(trichlorotitanio)propionate

D

C9H19Cl3O2SiTi

Conditions
ConditionsYield
With titanium tetrachloride In chloroform-d1 Product distribution; Mechanism;
...Expand
85909-11-1

Aminodichlorphosphan

A

C6H15ClNPSi

B

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
at 319.84℃; Thermolysis;
18163-07-0

2-(trimethylsilyl)propene

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH4F*HF, H2SO4
2: ClSiMe3, AlCl3
View Scheme
288-32-4

1H-imidazole

389625-48-3

7'-chloro-4'-methylfluorescein

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In N,N-dimethyl-formamide
677-22-5

tert-butylmagnesium chloride

75-78-5

dimethylsilicon dichloride

18162-48-6

tert-butyldimethylsilyl chloride

288-32-4

1H-imidazole

192376-55-9

(2R)-4-(3-pyridyl)-1,2-butanediol

98-59-9

p-toluenesulfonyl chloride

A

192376-56-0

(2R)-2-(tert-butyldimethylsilyloxy)-4-(pyridin-3-yl)-1-(4-toluenesulfonyloxy)butane

B

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In pyridine; dichloromethane
...Expand
29681-57-0

tert-butyldimethylsilane

7681-65-4

copper(I) iodide

7447-39-4

copper(II) chloride

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In tetrahydrofuran
...Expand
91-16-7

1,2-dimethoxybenzene

29681-57-0

tert-butyldimethylsilane

75-78-5

dimethylsilicon dichloride

A

1066-35-9

dimethylmonochlorosilane

B

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
AlCl3A n/a
B 91% and 92%
...Expand
288-32-4

1H-imidazole

7646-93-7

potassium hydrogensulfate

18162-48-6

tert-butyldimethylsilyl chloride

Conditions
ConditionsYield
In N-methyl-acetamide
3736-77-4

2,2'-Anhydrouridine

18162-48-6

tert-butyldimethylsilyl chloride

55264-11-4

(2R,3R,3aS,9aR)-3-((tert-butyldimethylsilyl)oxy)-2-(((tert-butyldimethylsilyl)oxy)methyl)-3,3a-dihydro-2H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6(9aH)-one

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 2h; Inert atmosphere;100%
With 1H-imidazole In N,N-dimethyl-formamide for 3h; Ambient temperature;92%
With pyridine; 1H-imidazole Ambient temperature;61%
With 1H-imidazole
With 1H-imidazole In N,N-dimethyl-formamide for 1h;
818-72-4

1-Octyn-3-ol

18162-48-6

tert-butyldimethylsilyl chloride

60134-93-2

3-(tert-butyldimethylsilyloxy)oct-1-yne

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide for 8h; Ambient temperature;100%
With 1H-imidazole silylation;99%
With 1H-imidazole; dmap In dichloromethane at 0 - 20℃; for 20h;99%
79-14-1

glycolic Acid

18162-48-6

tert-butyldimethylsilyl chloride

67226-76-0

(tert-butyldimethylsiloxy) acetic acid tert-butyldimethylsilyl ester

Conditions
ConditionsYield
With pyridine for 2h; Ambient temperature;100%
With 1H-imidazole In N,N-dimethyl-formamide for 10h; Ambient temperature;97%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;95%
5390-04-5

pent-1-yn-5-ol

18162-48-6

tert-butyldimethylsilyl chloride

61362-77-4

1-(tert-butyldimethylsilyloxy)-4-pentyne

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 25℃;100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 4h; Inert atmosphere;100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 0.5h; Inert atmosphere;100%
14320-38-8

cyclopent-3-enol

18162-48-6

tert-butyldimethylsilyl chloride

68845-72-7

4-tert-butyldimethylsilyloxycyclopentene

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃;100%
With 1H-imidazole In dichloromethane at 0 - 20℃; for 16.5h;100%
With 1H-imidazole In tetrahydrofuran at 0℃;95%
18162-48-6

tert-butyldimethylsilyl chloride

100-51-6

benzyl alcohol

53172-91-1

(benzyloxy)(tert-butyl)dimethylsilane

Conditions
ConditionsYield
With P(MeN(CH3)CH2CH2)3N; triethylamine In acetonitrile at 24℃; for 2.5h;100%
With ferric hydrogen sulphate; triethylamine In acetonitrile at 20℃; for 60h; Inert atmosphere; chemoselective reaction;100%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 0.5h;99%
109-99-9

tetrahydrofuran

18162-48-6

tert-butyldimethylsilyl chloride

92511-12-1

1-{[dimethyl(1,1-dimethylethyl)silyl]oxy}-4-iodobutane

Conditions
ConditionsYield
With sodium iodide In acetonitrile at 55℃; for 16h; Inert atmosphere;100%
With sodium iodide In tetrahydrofuran; acetonitrile at 55℃; for 18h; Inert atmosphere;100%
With sodium iodide In acetonitrile at 20℃; Inert atmosphere; Darkness;93%
98-00-0

(2-furyl)methyl alcohol

18162-48-6

tert-butyldimethylsilyl chloride

121389-55-7

tert-butyl(furan-2-ylmethoxy)dimethylsilane

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at -78 - 20℃;100%
With 1H-imidazole In N,N-dimethyl-formamide99%
With 1H-imidazole In N,N-dimethyl-formamide at 23℃; for 0.5h;97%
4412-91-3

furan-3-methanol

18162-48-6

tert-butyldimethylsilyl chloride

89861-06-3

tert-butyl (furan-3-ylmethoxy)dimethylsilane

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 2h;100%
With 1H-imidazole In dichloromethane100%
With N-ethyl-N,N-diisopropylamine In dichloromethane for 1h; Ambient temperature;98%
120-72-9

indole

18162-48-6

tert-butyldimethylsilyl chloride

40899-73-8

N-tert-butyldimethylsilylindole

Conditions
ConditionsYield
Stage #1: indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h;
Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃;		100%
Stage #1: indole With sodium hydride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 0.5h;
Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide; mineral oil at 0 - 20℃; for 1h;		100%
Stage #1: indole With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃; for 0.75h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil at 0 - 20℃; for 12h; Inert atmosphere;		93%
586-95-8

pyridine-4-methanol

18162-48-6

tert-butyldimethylsilyl chloride

117423-41-3

4-((tert-butyldimethylsilyloxy)methyl)pyridine

Conditions
ConditionsYield
With 1H-imidazole In DMF (N,N-dimethyl-formamide) for 3.25h;100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;100%
Stage #1: tert-butyldimethylsilyl chloride With 1H-imidazole In dichloromethane; N,N-dimethyl-formamide for 0.166667h; Inert atmosphere;
Stage #2: pyridine-4-methanol In dichloromethane; N,N-dimethyl-formamide at 20℃; for 13h; Inert atmosphere;		99%
67-47-0

5-hydroxymethyl-2-furfuraldehyde

18162-48-6

tert-butyldimethylsilyl chloride

155108-06-8

5-(((tert-butyldimethylsilyl)oxy)methyl)furan-2-carbaldehyde

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 24h; Inert atmosphere;100%
Stage #1: 5-hydroxymethyl-2-furfuraldehyde With 1H-imidazole In dichloromethane at 20℃; for 0.25h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In dichloromethane at 20℃; Inert atmosphere; Darkness;		99%
With potassium carbonate In dichloromethane at 20℃; for 12h;99%
62147-49-3

1,3-dihydroxyacetone dimer

18162-48-6

tert-butyldimethylsilyl chloride

127382-65-4

1,3-bis-O-(tert-butyldimethylsilyl)-1,3-dihydroxy-2-propanone

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane for 18h;100%
With triethylamine In dichloromethane at 20℃; for 12h;99%
With 1H-imidazole In N,N-dimethyl-formamide for 3h; Ambient temperature;98%
526-55-6

2-(3-indole)-ethanol

18162-48-6

tert-butyldimethylsilyl chloride

101079-48-5

3-(2-((tert-butyldimethylsilyl)oxy)ethyl)-1H-indole

Conditions
ConditionsYield
With 1H-imidazole In tetrahydrofuran at 0 - 20℃; for 0.5h; Inert atmosphere;100%
With 1H-imidazole In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;100%
With 1H-imidazole In N,N-dimethyl-formamide for 16h; Ambient temperature;99%
5631-67-4

7-hydroxychroman-2-one

18162-48-6

tert-butyldimethylsilyl chloride

82861-23-2

7-((tert-butyldimethylsilyl)oxy)chroman-2-one

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 25℃; for 10h;100%
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;91%
951-78-0

2'-deoxyuridine

18162-48-6

tert-butyldimethylsilyl chloride

64911-18-8

3',5'-O-di(tert-butyldimethylsilyl)-2'-deoxyuridine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; for 3h;100%
With pyridine; 1H-imidazole at 0 - 20℃;100%
With 1H-imidazole In N,N-dimethyl-formamide Etherification;97%
59-14-3

5-bromo-2'-deoxyuridine

18162-48-6

tert-butyldimethylsilyl chloride

154925-95-8

3',5'-di-O-(tert-butyldimethylsilyl)-5-bromo-2'-deoxyuridine

Conditions
ConditionsYield
With pyridine at 40℃; for 20h; Inert atmosphere;100%
With 1H-imidazole; dmap In N,N-dimethyl-formamide at 20℃; for 12h;99%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 60h;96%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 1.5h;94%
With TEA In tetrahydrofuran at 75℃; for 40h;65%
2408-36-8

lithium cyanide

108-94-1

cyclohexanone

18162-48-6

tert-butyldimethylsilyl chloride

114114-74-8

1-<(tert-butyldimethylsilyl)oxy>-1-cyanocyclohexane

Conditions
ConditionsYield
In tetrahydrofuran for 70h; Ambient temperature;100%
...Expand
961-07-9

2'-Deoxyguanosine

18162-48-6

tert-butyldimethylsilyl chloride

51549-35-0

3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;100%
With 1H-imidazole In N,N-dimethyl-formamide silylation;97%
With 1H-imidazole In N,N-dimethyl-formamide; toluene for 3h; Inert atmosphere; Heating; Large scale;97%
123-08-0

4-hydroxy-benzaldehyde

18162-48-6

tert-butyldimethylsilyl chloride

120743-99-9

p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran100%
With dmap; triethylamine In [D3]acetonitrile at 25℃; for 0.2h;99%
With triethylamine In dichloromethane at 20℃; for 2h;98%
90-02-8

salicylaldehyde

18162-48-6

tert-butyldimethylsilyl chloride

116585-12-7

2-((tert-butyldimethylsilyl)oxy)benzaldehyde

Conditions
ConditionsYield
With dmap; triethylamine In dichloromethane at 20℃; for 1h;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃; for 12h; Schlenk technique; Glovebox;100%
121-33-5

vanillin

18162-48-6

tert-butyldimethylsilyl chloride

69404-94-0

O-tert-butyldimethylsilylvanillin

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane at 20℃; for 2h;100%
With 1H-imidazole; dmap In dichloromethane at 20℃; Inert atmosphere;100%
With 1H-imidazole; dmap In dichloromethane at 20℃; for 2h;100%
107-21-1

ethylene glycol

18162-48-6

tert-butyldimethylsilyl chloride

102229-10-7

2-(tert-butyldimethylsilyloxy)ethanol

Conditions
ConditionsYield
With triethylamine In dichloromethane for 0.166667h; Cooling with ice;100%
With dmap; triethylamine In dichloromethane at 0 - 20℃;99%
With pyridine at 20℃; for 2h; Inert atmosphere;99%
621-59-0

isovanillin

18162-48-6

tert-butyldimethylsilyl chloride

97315-18-9

p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide at 20℃;100%
With 2-(Dimethylamino)pyridine; triethylamine In dichloromethane at 0 - 20℃; for 12h;100%
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran; N,N-dimethyl-formamide Inert atmosphere;100%
97-64-3, 2676-33-7

ethyl 2-hydroxypropionate

18162-48-6

tert-butyldimethylsilyl chloride

105198-38-7

(S)-(-)-ethyl 2-(tert-butyldimethylsilyloxy)propanoate

Conditions
ConditionsYield
With 1H-imidazole In dichloromethane a) RT, overnight, b) reflux, 10 h;100%
With 1H-imidazole
With 1H-imidazole In dichloromethane Ambient temperature;
With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 12h;
821-41-0

5-Hexen-1-ol

18162-48-6

tert-butyldimethylsilyl chloride

85807-84-7

tert-butyl(5-hexenyloxy)dimethylsilane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide100%
With 1H-imidazole In tetrahydrofuran at 20℃;100%
With 1H-imidazole In dichloromethane at 20℃; for 19h;100%
1191-25-9

6-Hydroxyhexanoic acid

18162-48-6

tert-butyldimethylsilyl chloride

77744-44-6

6-(tert-butyldimethylsilyloxy)hexanoic acid

Conditions
ConditionsYield
Stage #1: 6-Hydroxyhexanoic acid With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 0.166667h;
Stage #2: tert-butyldimethylsilyl chloride In N,N-dimethyl-formamide at 20℃; for 0.5h;		100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 0.25h;87%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; Inert atmosphere;86%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃;80%
With 1H-imidazole In N,N-dimethyl-formamide at 50℃; Inert atmosphere;
50622-09-8

2,3-O-isopropylidene-L-threitol

18162-48-6

tert-butyldimethylsilyl chloride

108817-96-5

[(4S,5S)-5-[(tert-butyl(dimethyl)silyl)oxymethyl]-2,2-dimethyl-1,3-dioxolan-4-yl]methanol

Conditions
ConditionsYield
Stage #1: 2,3-O-isopropylidene-L-threitol With sodium hydride In tetrahydrofuran at 0 - 20℃;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 16h;		100%
With 1H-imidazole; dmap In dichloromethane at 20℃; for 3h; Inert atmosphere;100%
Stage #1: 2,3-O-isopropylidene-L-threitol With sodium hydride In tetrahydrofuran at 20℃; for 0.75h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran at 20℃; for 0.75h; Inert atmosphere;		98%
106-44-5

p-cresol

18162-48-6

tert-butyldimethylsilyl chloride

62790-85-6

tert-Butyl(dimethyl)-(4-methylphenoxy)silane

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide100%
With 1H-imidazole In N,N-dimethyl-formamide at 20℃; for 16h;99%
With 1H-imidazole; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate at 20℃; for 2h;97%
371-41-5

4-Fluorophenol

18162-48-6

tert-butyldimethylsilyl chloride

113984-68-2

4-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene

Conditions
ConditionsYield
With 1H-imidazole In N,N-dimethyl-formamide at 20℃;100%
With 1H-imidazole In N,N-dimethyl-formamide at 25℃; for 12h;98%
With 1H-imidazole In N,N-dimethyl-formamide at 0℃; for 1h;91%
Raw Materials
93-61-8
98-59-9
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  • tert-Butyldimethylsilyl chloride Manufacturer/High quality/Best price/In stock

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride Manufacturer/High quality/Best price/In stock

    Min.Order: 1 Kilogram

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    DayangChem exported this product to many countries and regions at best price. If you are looking for the material's manufacturer or supplier in China, DayangChem is your best choice. Pls contact with us freely for getting detailed product spe

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  •  Dayang Chem (Hangzhou) Co.,Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 0

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    LEAPChem supplies 200,000 of raw materials, specialty chemicals, fine chemicals, building blocks and advanced intermediates. Purity: 98% - 99%. Each product is checked by Quality

  •  LEAP CHEM Co., Ltd.

    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+852-30606658

    Address:EASEY COMM BLDG 253-261 HENNESSY ROAD Hong Kong, China

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 1 Gram

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    Product Description Product website: http://www.finerchem.com/pro01en/id/2014.html Product Name tert-Butyldimethylsilyl chloride CAS No. 18162-48-6

    Jinan Finer Chemical Co., Ltd is established under the support of Jinan city government, so it has many advantages in company credibility, finance safe, product quality control and

  •  Jinan Finer Chemical Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-531-88989536

    Address:New Material Industry Park, Jinan Ciyt, China

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  • Tert-butyl dimethyl chloro silane

  • Casno:

    18162-48-6

    Tert-butyl dimethyl chloro silane

    Min.Order: 100 Kilogram

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    best price ,best quality capacity 500mt/y Application:Pharamceutical intermediate

    Established in 1943 as one of the national largest manufacturing and exporting bases in the chemical synthetic pharmaceuticals field, Shandong Xinhua Pharmaceutical Company Limited

  •  Shandong Xinhua Pharmaceutical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-533-2196801

    Address:1 lutai road,zhangdian dis,Zibo City

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  • High quality Tert-Butyldimethylsilyl Chloride supplier in China

  • Casno:

    18162-48-6

    High quality Tert-Butyldimethylsilyl Chloride supplier in China

    Min.Order: 1 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

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  •  Simagchem Corporation

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-592-2680277

    Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

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  • Tert-butyldimethylsilyl chloride manufaturer

  • Casno:

    18162-48-6

    Tert-butyldimethylsilyl chloride manufaturer

    Min.Order: 23 Metric Ton

    FOB Price:  USD $ 0.0-0.0/Metric Ton

    1.We are not just a manufacturer but aslo a trading company.Our office located in Hangzhou. 2.We have document department who can meet customers' documentary requirements. 3.We have many cooperative plants who can provide price support for

    Orchid Chemical was established in 2009; we are headquartered in Hangzhou, which is 200 km from China's biggest sea port, Shanghai. Orchid chemical is a joint-venture company, com

  •  ORCHID CHEMICAL SUPPLIES LTD

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86-571-85395792

    Address:607, North Zhongshan Road, Hangzhou 310000 China

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  • Amadis Chemical offer CAS#18162-48-6;CAT#A812625

  • Casno:

    18162-48-6

    Amadis Chemical offer CAS#18162-48-6;CAT#A812625

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    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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  • tert-Butylchlorodimethylsilane

  • Casno:

    18162-48-6

    tert-Butylchlorodimethylsilane

    Min.Order: 0

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    Chemwill Asia co.,Ltd is one of the leading manufacturer in CHINA.Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Active pharmaceutical ingredients(APIs), Veterinary, Indole derivatives, Aro

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  •  Chemwill Asia Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 1 Kilogram

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    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,and we are dedicated to developing and manufacturing new ap

    Cangzhou Enke Pharma Tech Co.,ltd. is located in Cangzhou City, Hebei province ,where is a famous petroleum chemical industry city in China. Enke Pharma a high-tech enterprise ,an

  •  Enke Pharma-tech Co.,Ltd. （Cangzhou, China ）

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:0086-317-5105699

    Address:40# Shuiyuesi Street, Cangzhou City,Hebei Province, China.

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 1 Kilogram

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    Product Name Tert-Butyldimethylsilyl chloride CAS No. 18162-48-6 Appearance White Crysstalline Powder Assay ≥99.0% Appearance: white powder

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  •  Henan Sinotech Import&Export Corporation

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-371-86181678

    Address:No. 260, Dongming Road,Jinshui District

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  • TIANFU-CHEM 18162-48-6 tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    TIANFU-CHEM 18162-48-6 tert-Butyldimethylsilyl chloride

    Min.Order: 1 Kilogram

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    Our company engages in Electronic chemicals such as OLED，Photoresist chemical，Electrolyte additive and Intermediate Pharmaceutical production; development of noble metal catalysts,

  •  Henan Tianfu Chemical Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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  • tert-Butyldimethylsilyl chloride/TBSCl CAS No.:18162-48-6

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride/TBSCl CAS No.:18162-48-6

    Min.Order: 100 Gram

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    1. Guaranteed purity; 2. Large quantity in stock; 3. Largest manufacturer; 4. Best service after shipment with email; 5. High quality & competitive price; Appearance:White crystalline granules or powder. Storage:Store in seale

    Hubei Xinrunde Chemical Co., Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredient(s)

  •  Hubei XinRunde Chemical Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8618874586545

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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  • New production CAS 18162-48-6 with best quality

  • Casno:

    18162-48-6

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    Zhuo Zhou Wen Xi Import and Export Co., Ltd. is a company mainly engaged in the export of pharmaceutical raw materials. Its parent company is （Wen Xi Pharma）, including three subs

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 1 Kilogram

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    We are Hebei miaobian Biotechnology Co., Ltd , mainly deal in pharmaceutical intermediates and various chemicals. It is with a registered capital of 3 million yuan, is one of the m

  •  Hebei miaobian Biotechnology Co., Ltd

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:15032793961

    Address:Federal Business Plaza, Qiaoxi District,Shijiazhuang

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  • Good supplierTert-Butyldimethylsilyl Chloride for Fulvestrant

  • Casno:

    18162-48-6

    MSDS/COA Download

    Good supplierTert-Butyldimethylsilyl Chloride for Fulvestrant

    Min.Order: 10 Gram

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     China (Mainland)  |  Contact Details

    Business Type:Other

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  • Casno:

    18162-48-6

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    1.No Less 8 years exporting experience. Clients can 100% received goods 2.Lower Price with higher quality 3,Free sample 4,We are sincerely responsible for the "product quality" and "After Service" Upbio is Specialized

    Shanghai Upbio Tech Co.,Ltd (Former Onchem (China)Co.,Ltd) is a comprehensive manufacturer and an international distribution of chemicals throughout the world, The predecessor of

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

    Address:No.2 Floor,No.979 Yunhan Rd,Nicheng,Pudong New Area,Shanghai,China

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:86-917-3909592

    Address:China

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  • Tert-butyldimethylsilyl chloride /High quality/Best price/In stock

  • Casno:

    18162-48-6

    MSDS/COA Download

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     China (Mainland)  |  Contact Details

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    Address:Room 302, 47 Changping Street, Chaoyang District, Changchun, Jilin Province,China

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  • Casno:

    18162-48-6

    99% Tert-Butyldimethylsilyl chloride CAS:18162-48-6

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    18162-48-6

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:18092428356

    Address:Weiyang District

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  • tert-Butyldimethylsilyl chloride CAS NO.18162-48-6

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride CAS NO.18162-48-6

    Min.Order: 1 Gram

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8613397160123

    Address:13th Floor, Tower B, Century Plaza, Zhongnan Road, Wuchang District, Wuhan, China.

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  • Tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    Tert-Butyldimethylsilyl chloride

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 50.0-50.0/Kilogram

    High purity ,low price BDCS;BDCS SILYLATION REAGENT;CB2790;chloro(1,1-dimethylethyl)dimethyl-silan;chloro(1,1-dimethylethyl)dimethyl-Silane;chloro-tert-butyldimethyl-silan;Chloro-tert-butyldimethylsilane;Dimethyl-tert-butylchlorosilane Appearance

    Who we are ? Located in Zhengzhou City, China , Henan Daken Chemical Co.,Ltd was Established in June ,1983.We have a 35 years history for fine chemical synthesis .Daken has young

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-371-55541817

    Address:No.56 Hongzhuan Road,Jinshui,Zhengzhou,450000,China

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  • Cas No: 18162-48-6 Tert-butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    Cas No: 18162-48-6 Tert-butyldimethylsilyl chloride

    Min.Order: 10 Metric Ton

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619930503256

    Address:No.66, Yuhua West Road

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 10 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    tert-Butyldimethylsilyl chloride Basic information Product Name: tert-Butyldimethylsilyl chloride Synonyms: BDCS;BDCS SILYLATION REAGENT;CB2790;chloro(1,1-dimethylethyl)dimethyl-

    CUSTOMIZED LAB Chemtn Biological Technology Limited is one of the leading RC chemicals producer in china,we have advanced equipment and high technology,

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    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+8615630194059

    Address:LB BLDG,Qiaoxi district,Shijiazhuang,china

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  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride 18162-48-6

    Min.Order: 1 Kilogram

    FOB Price:  USD $ 1.0-9999.0/Kilogram

    Changzhou Pesan Chemical Co., Ltd. is a dynamic and professional chemical company. Since its establishment, We provide raw materials and intermediates for the pharmaceutical industry and organic electronic materials. All of our staff have a chem

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+86 021 61559630

    Address:No.7-9,Guanghua St.,Zhonglou District,Changzhou,China

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  • Casno:

    18162-48-6

    Tert-Butyldimethylsilyl Chloride ( TBMS )

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    Best quality & Attractive price & Professional service; Trial & Pilot & Commercial Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, specia

    Hisunny Chemical is a leading manufacturer and supplier of chemicals in China. We develop produce and distribute high quality intermediates, special chemicals and OLED materials &

  •  Xiamen Hisunny Chemical Co.,Ltd

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-592-3327115

    Address:Unit 603,No.879,Xiahe Road,Meixin Building,Xiamen,China

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  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

    Min.Order: 25 Kilogram

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    ProductName:tert-Butyldimethylsilylchloride Synonyms:BDCS;BDCSSILYLATIONREAGENT;CB2790;chloro(1,1-dimethylethyl)dimethyl-silan;chloro(1,1-dimet…Appearance:Colorless translucent solid Storage:Store at 5°C Package:25kg drums Transportation:by se

    QINGDAO ON-BILLION INDUSTRIAL CO.,LTD was established in 2004 with registered capital RMB 26 million. （Former Qingdao on-billion imp&exp co.,ltd was founded in 1993 ） Awarded as E

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    Business Type:Trading Company

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    18162-48-6

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  •  Career Henan Chemical Co

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-371-86658258

    Address:Building 3 of Innovation Park, East District of the National University Science Park

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  • t-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    t-Butyldimethylsilyl chloride

    Min.Order: 1 Gram

    FOB Price:  USD $ 0.0-0.0/Gram

    Betterbiochem is specialized in APIs, pharmaceutical intermediates & fine chemicals. 1. The best quality, competitive price. 2. The best service before or after shipment. 3. Rich experience in export operation. 4. Rich experience in

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-18013506594

    Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China

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  • tert-Butyldimethylchlorosilane in China /favorable price /best quality 18162-48-6

  • Casno:

    18162-48-6

    tert-Butyldimethylchlorosilane in China /favorable price /best quality 18162-48-6

    Min.Order: 1 Kilogram

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  • Tert-Butyldimethylsilyl chloride

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    Tert-Butyldimethylsilyl chloride

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  • tert-Butyldimethylsilyl chloride

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    tert-Butyldimethylsilyl chloride

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    tert-Butyldimethylsilyl chloride

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  • tert-Butyldimethylsilyl chloride

  • Casno:

    18162-48-6

    tert-Butyldimethylsilyl chloride

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Reported in EPA TSCA Inventory.

Specification

The tert-Butyldimethylsilyl chloride, with the CAS registry number 18162-48-6,is also known as TBSCl; tert-Butylchlorodimethylsilane; t-Butyldimethylsilyl chloride; t-Butyldimethylchlorosilane. It belongs to the product categories of organosilicon compounds;Miscellaneous Reagents.Its EINECS number is 242-042-4. This chemical's molecular formula is C6H15ClSi and molecular weight is 150.72. What's more,Its systematic name is Ttert-Butylchlorodimethylsilane .It is a White solid which is Flammable, Corrosive and Moisture Sensitive.The tert-Butylchlorodimethylsilane (CAS NO.18162-48-6) is used for pharmaceutical intermediates, and is also used in organic synthesis as hydroxyl protectant.

Physical properties about tert-Butyldimethylsilyl chloride are:
(1)ACD/LogP:  2.833; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  2.83; (4)ACD/LogD (pH 7.4):  2.83; (5)ACD/BCF (pH 5.5):  83.82; (6)ACD/BCF (pH 7.4):  83.82; (7)ACD/KOC (pH 5.5):  828.61; (8)ACD/KOC (pH 7.4):  828.61; (9)#H bond acceptors:  0; (10)#H bond donors:  0; (11)#Freely Rotating Bonds:  1; (12)Index of Refraction:  1.411; (13)Molar Refractivity:  43.378 cm3; (14)Molar Volume:  174.746 cm3; (15)Surface Tension:  18.7350006103516 dyne/cm; (16)Density:  0.863 g/cm3; (17)Flash Point:  22.778 °C; (18)Enthalpy of Vaporization:  34.789 kJ/mol; (19)Boiling Point:  124.999 °C at 760 mmHg; (20)Vapour Pressure:  15.0319995880127 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES:Cl[Si](C(C)(C)C)(C)C;
(2)Std. InChI:InChI=1S/C6H15ClSi/c1-6(2,3)8(4,5)7/h1-5H3;
(3)Std. InChIKey:BCNZYOJHNLTNEZ-UHFFFAOYSA-N.

The toxicity data of tert-Butyldimethylsilyl chloride are as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 1gm/kg (1000mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,