Synthesis of N-(2-guanidinoethyl)-tetrahydrothieno[3,2-c]azepine, N-(2- guanidinoethyl)-tetrahydro-2-benzazepine and N-(2-guanidinoethyl)-tetrahydro- 1-benzazepine as analogous to antihypertensive agent guanetidine

Article abstract of DOI:10.1080/00397919408011191

N-(2-guanidinoethyl)-tetrahydrothieno[3,2-c]azepine 10a, N-(2- guanidinoethyl)-tetrahydro-2-benzazepine 10b and N-(2-guanidinoethyl)- tetrahydro-1-benzazepine 10c analogous of the antihypertensive agent Guanetidine were prepared by cyanomethylation of the corresponding azepines, reduction and subsequent guanilation of the resulting aminoethyl derivatives. These compounds were evaluated for antihypertensive activity in SHR rats but no significant activity was observed.

Full text of DOI:10.1080/00397919408011191

Synthetic Communications
ISSN: 0039-7911 (Print) 1532-2432 (Online) Journal homepage: http://www.tandfonline.com/loi/lsyc20
Synthesis of N-(2-Guanidinoethyl)-
tetrahydrothieno[3,2-c]azepine, N-(2-
Guanidinoethyl)-tetrahydro-2-benzazepine and N-
(2-Guanidinoethyl)-tetrahydro-1-benzazepine as
Analogous to Antihypertensive Agent Guanetidine
Enriqiie Ravina , Rosario G. Ramos , Christian F. Masaguer & Gerard0 Garcia
Mera
To cite this article: Enriqiie Ravina , Rosario G. Ramos , Christian F. Masaguer & Gerard0
Garcia Mera (1994) Synthesis of N-(2-Guanidinoethyl)-tetrahydrothieno[3,2-c]azepine,
N-(2-Guanidinoethyl)-tetrahydro-2-benzazepine and N-(2-Guanidinoethyl)-tetrahydro-1-
benzazepine as Analogous to Antihypertensive Agent Guanetidine, Synthetic Communications,
24:3, 321-332
To link to this article: http://dx.doi.org/10.1080/00397919408011191
Published online: 23 Sep 2006.
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Date: 29 January 2016, At: 09:53