Chemistry Letters p. 2295 - 2298 (1994)
Update date:2022-08-11
Topics:
Hashizume, Kazunari
Hashimoto, Naoto
Cork, David G.
Miyake, Yoshihiro
A rapid micro-scale synthesis of fluorinated neuroleptics with extremely high chemical purity was accomplished using a new single column reverse-phase HPLC purification procedure that employs a strongly alkaline eluent to clearly separate F-labeled compounds from the large excess of nitro or chloro precursor.The method is applicable to the production of 18F-labeled positron emission tomography (PET) tracer with high specific activity.
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