Selective bromination of ketones. A convenient synthesis of 5-aminolevulinic acid

Article abstract of DOI:10.1080/00397919408010567

Bromination of unsymmetrical ketones with Br₂ in methanol proceeded regioselectively in good yield at the less substituted methyl carbon. The bromination of levulinic acid using this method was followed by azidation and amination to lead to an efficient three-step synthesis of 5-aminolevulinic acid in 36% overall yield.

Full text of DOI:10.1080/00397919408010567

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Synthetic Communications: An
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Selective Bromination of
Ketones. A Convenient
Synthesis of 5-Aminolevulinic
Acid
Hyun-Joon Ha a , Sung-Koo Lee a , Young-Jin Ha a
Jun-Weon Park a
&
a Department of Chemistry, Hankuk University of
Foreign Studies Yongin-Gun, Kyunggi-Do, 449-791,
Korea
Version of record first published: 23 Sep 2006.
To cite this article: Hyun-Joon Ha , Sung-Koo Lee , Young-Jin Ha & Jun-Weon Park
(1994): Selective Bromination of Ketones. A Convenient Synthesis of 5-Aminolevulinic
Acid, Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 24:18, 2557-2562
To link to this article: http://dx.doi.org/10.1080/00397919408010567
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