Cytotoxic activity of marine algae and a cytotoxic principle of the brown alga Sargassum tortile

Article abstract of DOI:10.1248/cpb.39.2129

Partition fractions of hexane, CCl₄ and CHCl₃ from methanolic extracts of marine algae were each examined for cytotoxic activities against cultured P-388 lymphocytic leukemia cells. Cytotoxic activities were found for partition fractions of 21 species of seaweed. Bioactivity-guided fractionation of the CCl₄ partition fraction from Sargassum tortile, exhibiting the most prominent activity, afforded dihydroxysargaquinone (1) and sargatriol (2) previously isolated from this alga. The former was evaluated as a cytotoxic principle, and the latter, showing moderate activity, was suggested to be an artifact derived from 1 during the isolation procedure.

Full text of DOI:10.1248/cpb.39.2129

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