The N-(2-hydroxybenzyl) protecting group for amide bond protection in solid phase peptide synthesis

Article abstract of DOI:10.1016/0040-4039(94)85081-X

Backbone amide protection using the N-(2-hydroxybenzyl) group to overcome chain aggregation during solid phase peptide synthesis is described. This is illustrated by the preparation of the notoriously difficult decapeptide acyl carrier protein (65-74). Th