Synthesis of the bi-heterocyclic parent ring system 1,2,4-triazolo[4,3- b][1,2,4,5]tetrazine and some 3,6-disubstituted derivatives

Article abstract of DOI:10.1002/jhet.5570350616

The synthesis of the previously unknown parent ring system was developed. Treatment of 3-hydrazino-1,2,4,5-tetrazine (4) with diethoxymethyl acetate gave the parent ring system. Similar treatment of 3-(3,5- dimethylpyrazol-1-yl)-6-hydrazino-1,2,4,5-tetrazine (2) with one carbon cyclizing reagents gave 3,6-di-substituted derivatives of the 1,2,4-tetrazine ring system.