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Factory Supply Zinc Pyrithione (ZPT)
Cas No: 13463-41-7
No Data 1 Gram 1000 Metric Ton/Day Ality Chemical Corporation Contact Supplier
Zinc pyrithione
Cas No: 13463-41-7
No Data No Data No Data Aecochem Corp. Contact Supplier
Zinc pyrithione
Cas No: 13463-41-7
USD $ 5.0-5.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
Factory supply Zinc pyrithione (ZPT) Cas 13463-41-7 with top quality low price
Cas No: 13463-41-7
USD $ 65.0-65.0 / Kilogram 1 Kilogram 3000 Kilogram/Month Wuhan Fortuna Chemical Co.,Ltd Contact Supplier
ZPT 97%
Cas No: 13463-41-7
No Data 25 Kilogram Metric Ton/Day taicang liyuan chemical co,.ltd Contact Supplier
Zinc pyrithione
Cas No: 13463-41-7
No Data No Data No Data Shanghai Rich Chemicals Co., Ltd Contact Supplier
Zinc Pyrithione
Cas No: 13463-41-7
No Data No Data 10 Metric Ton/Month Shanghai SMEC Trading Co., Ltd. Contact Supplier
Zinc pyrithione Manufacturer/High quality/Best price/In stock
Cas No: 13463-41-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High purity Various Specifications 1-hydroxypyridine-2-thione zinc CAS:13463-41-7
Cas No: 13463-41-7
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Zinc pyrithione supplier in China
Cas No: 13463-41-7
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier

13463-41-7 Usage

Uses

Shampoo for dandruff,zinc pyrithione can inhibit Gram positive and negative bacteria and mold growth,Care hair Effectively , delay hair aging ,control white hair and hair loss generation. zinc pyrithion is also used as a cosmetic preservative, oil, paint biocide. Zinc pyrithione has a strong killing power on fungi and bacteria so that it can effectively kill dandruff fungus,playing a role in dandruff .

Uses

Zinc pyrithione is directly cytotoxic and has antimicrobial effects. Zinc pyrithione is found in many shampoos (DHS-Zinc, Head and Shoulders) and should be applied for 5 minutes daily for 2 weeks. Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.

Brand name

Head & Shoulders Conditioner (Procter & Gamble).

Uses

zinc pyrithione is a preservative against bacteria, fungi, and yeast. It is unstable in light and in the presence of oxidizing agents. Zinc pyrithione is useful in gels, creams, heavy lotions, and talcum powder.

General Description

Fine beige granules.

Product description

Zinc pyrithione is the pyrithione complexes of zinc bromide, in the early 1930s, was already synthesized and used as a topical antifungal or antibacterial agent. At room temperature it is white to yellow crystalline powder. Slight characteristic odor. Insoluble in water. Solubility: water 15mg/kg; pH = 8 Water 35mg/kg; Ethanol 100mg/kg; polyethylene glycol (PEG400) 2000mg/kg. A pH optimum range of 4.5 to 9.5; mass fraction of 10% suspension pH3.6. Zinc pyrithione react with cationic and non-ionic surfactants forming insoluble precipitate, unstable in the light and oxidizer, when at higher temperatures ,it is not stable to acids and bases . It is not compatible with EDTA, non-ionic surfactants make it partially deactivated. When with the presence of heavy metals, chelation or anti-sequestration will occur, and these chelates are insoluble in water. EEC and GB7916-87 provide that maximum allowable concentration of mass fraction of zinc pyrithione on cosmetics is 0.5%, only for cleaning after using products.General concentration 250~1000mg/kg (active), zinc pyrithione can be used in gels, creams, lotions, talcum powder and anti-dandruff shampoo, deodorant and also for disinfecting articles.

Efficacy

Zinc pyrithione shampoos (in concentrations between 1 to 2%) and shampoos with selenium sulide have been reported to be effective in the treatment of scalp psoriasis.However,their efficacy has not been substantiated by controlled studies.There is also some evidence that shampoos with antifungal agents (e.g.ketoconazole)can have a beneficial effect on scalp conditions. It should be noted, however, that the effectiveness of these shampoos is much smaller than these containing tars, corticosteroids or keratolytics.

Fire Hazard

Flash point data for Zinc pyrithione are not available, but Zinc pyrithione is probably combustible.

Chemical Properties

Beige granules

Safety Profile

Poison by ingestion, skin contact, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. An experimental teratogen. Experimental reproductive effects. An eye irritant. When heated to decomposition it emits very toxic fumes of NOx, SOx, and ZnO. Used as an anti- dandruff agent in shampoos. See also ZINC COMPOUNDS and SULFIDES.

Reactivity Profile

Organometallics, such as Zinc pyrithione, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases.

Indications

Zinc pyrithione is the active ingredient in several shampoos used to control dandruff and seborrheic dermatitis and is also effective in the therapy of tinea versicolor. It remains unclear whether the beneficial effects are caused by an antiproliferative or antimicrobial effect or both. It is substantive to the hair, allowing continued therapeutic effect after washing.

Toxicity evaluation

The toxicity of the active substance zinc pyrithione has been investigated in standard laboratory tests with a number of aquatic organisms living in fresh water (the green alga Selenastrum capricornutum, the crustacean Daphnia magna, the fish rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas)) and in seawater (the crustacean Mysidopsis bahia, the fish sheepshead minnow (Cyprinodon variegatus) and the oyster (Crassostrea virginica)) (Boeri et al. 1993; 1994a-e; Ward et al. 1994a). The results show that while zinc pyrithione and omadine disulfide were very toxic to aquatic organisms (L(E)C50 in the order of 3-300 μg/L), omadine sulfonic acid and pyridine sulfonic acid were considerably less toxic (L(E)C50 in the order of >20 mg/L) (Olin 1977). In a long-term study with fish eggs and larvae, pyridine sulfonic acid gave no effects at a concentration of 0.01 mg/L (Boeri et al. 1999). Algae were the group of organisms most sensitive to the last two substances.

Pharmaceutical Applications

Zinc pyrithione is a regulator of keratinization, selenium sulfide has antimicrobial properties and ketoconazole is an antifungal agent (i.e.can provide the reduction of the lipophilic yeast Malassezia furfur).

Photolysis

Zinc pyrithione is very rapidly transformed by photolysis. Experiments conducted under sterile conditions with a light:dark cycle of 12:12 hours have shown that, under exposure to light, the concentration of [pyridine-2,6-14C]zinc pyrithione in pH 9 buffer was reduced to 33% of the radioactivity added in 15 min. Data from this study also demonstrated that less than 5% of the 14C added occurred as zinc pyrithione after 1 hour of exposure to light. Similar results have been achieved when photolysis of zinc pyrithione was investigated by use of artificial seawater. In this study, the parent compound constituted 45% of the radioactivity added after 15 min while, after 24 hours, 1.3% of the added dose occurred as zinc pyrithione. The estimated half-lives of the photolytic transformation of zinc pyrithione was 13 min in pH 9 buffer and 17.5 min in artificial seawater (Reynolds 1995a). https://www2.mst.dk/udgiv/publications/2000/87-7944-084-3/html/kap04_eng.htm

Uses

Reactions may lead to photosensitive eczema and actinic reticuloid syndrome. Zinc pyrithione is used as antifungal, antibacterial and antiseborrheic agent used in many shampoos and hair creams.

Contact allergens

Zinc pyrithione is widely used in antidandruff shampoos and is a classic allergen. Concomitant reactions are expected to both zinc and sodium pyrithione.

Air & Water Reactions

Insoluble in water.
InChI:InChI=1/2C5H4NOS.Zn/c2*7-6-4-2-1-3-5(6)8;/h2*1-4H;/q2*-1;+2

13463-41-7 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (M0633)  2-Mercaptopyridine N-Oxide Zinc Salt  >98.0%(T) 13463-41-7 25g 550.00CNY Detail
TCI America (M0633)  2-Mercaptopyridine N-Oxide Zinc Salt  >98.0%(T) 13463-41-7 100g 1,520.00CNY Detail
TCI America (M0633)  2-Mercaptopyridine N-Oxide Zinc Salt  >98.0%(T) 13463-41-7 500g 4,800.00CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-10G 783.90CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-100G 4,036.50CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-10G 783.90CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-100G 4,036.50CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-10G 783.90CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-100G 4,036.50CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-10G 783.90CNY Detail
Aldrich (H6377)  1-Hydroxypyridine-2-thionezincsalt  ≥95% 13463-41-7 H6377-100G 4,036.50CNY Detail

13463-41-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name zinc pyrithione

1.2 Other means of identification

Product number -
Other names Zinc pyrithione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13463-41-7 SDS

13463-41-7Synthetic route

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc(II) chloride
7646-85-7

zinc(II) chloride

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
In water at 70℃; for 1.16667h; Product distribution / selectivity;99.1%
zinc(II) sulfate monohydrate
100685-55-0

zinc(II) sulfate monohydrate

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
In water
In water
zinc hydroxide nitrate hydrate

zinc hydroxide nitrate hydrate

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
With acetic acid In water aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(NO3)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d;
5Zn(2+)*8(OH)(1-)*2CH3CO2(1-)*99H2O=Zn5(OH)8[CH3CO2]2*99H2O

5Zn(2+)*8(OH)(1-)*2CH3CO2(1-)*99H2O=Zn5(OH)8[CH3CO2]2*99H2O

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
With acetic acid In water aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(CH3CO2)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d;
Zn5(OH)8(dodecylsulfate)2*99H2O

Zn5(OH)8(dodecylsulfate)2*99H2O

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
With acetic acid In water Kinetics; aq. soln. of sodium pyrithione titrated with glacial acetic acid to pH=6.5, Zn5(OH)8(dodecylsulfate)2*2H2O added, suspn. stirred for 5-120 min at room temp. under ambient pressure, quenched; ppt. centrifuged, washed with ethanol and deionized water (1:1,v:v), air-dried at 65 °C for 1 d;
zinc(II) nitrate
10196-18-6

zinc(II) nitrate

2-mercaptopyridine-1-oxide sodium salt
3811-73-2

2-mercaptopyridine-1-oxide sodium salt

zinc pyrithione
13463-41-7

zinc pyrithione

Conditions
ConditionsYield
In not given addn. of soln. of sodium salt of 1-hydroxypyridine-2-thione to Zn(II) nitrate soln. with stirring; pptn.; filtration; washing (water, ethanol, ether); drying in a desiccator overCaCl2; elem. anal.;

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