Journal of Pharmaceutical Sciences p. 224 - 226 (1985)
Update date:2022-08-16
Topics:
Debruyne
Moulin
Bricard
Bigot
A high-performance liquid chromatographic method is described which determines noxytiolin and 1-methyl-2-thiourea concentrations in serum. Valid determination requires immediate ultracentrifugation of blood samples, rapid serum freezing, and injection into the chromatograph within 6 h. A number of pharmacokinetic parameters were calculated from serum concentration data in rabbits and humans. An unknown metabolite was detected in both species but its structure was not identified.
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