An efficient and practical direct resolution of racemic 1,1'-bi-2-naphthol to both of its pure enantiomers

Article abstract of DOI:10.1016/0957-4166(95)00280-3

An efficient and practical method to directly resolve racemic 1,1'-bi-2-naphthol, rac-1, into optically pure R and S-1 has been developed by modification of a N-benzylcinchonidium chloride resolution procedure. In a typical experiment, 60 g of rac-1 is resolved to give 22.5 g of R-1 (75%, >99% ee) and 21 g of S-1 (70%, >99% ee). The chiral resolving agent, (8S,9R)-(-)-N-benzylcinchonidinium chloride, 2, is recovered in 80% yield.