75980-60-8

Usage

Uses

Used in Ink Industry:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is used as a photo initiator for the curing process in many kinds of ink industries. Its high reactivity and efficiency enable faster curing times and improved ink performance.
Used in Electronics Industry:
In the electronics industry, Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is used in the photo-crosslinking of PMMA composite, which can be further used as a gate insulator in organic thin film transistors (OTFTs). This application helps improve the performance and stability of electronic devices.
Used in Coatings Industry:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide is used in the formation of UV curable urethane-acrylate coatings. Its ability to initiate photo-crosslinking reactions allows for the creation of durable and high-quality coatings with excellent adhesion and resistance properties.
Used in Chemical Synthesis:
Diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide may also be used in the photoinduced reaction for the formation of organophosphine compounds. These compounds have potential applications as ligands with metal catalysts and reagents, further expanding the utility of this versatile photo initiator.

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C22H21O2P/c1-16-14-17(2)21(18(3)15-16)22(23)25(24,19-10-6-4-7-11-19)20-12-8-5-9-13-20/h4-15H,1-3H3

Synthetic route

α-hydroxy-(2,4,6-trimethylbenzyl)diphenyl phosphine oxide → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With manganese(IV) oxide In dichloromethane at 20℃;	98%
With vanadium(V) oxide; dihydrogen peroxide at 8 - 25℃; for 3.5h; Reagent/catalyst; Green chemistry;	96%
With tert.-butylhydroperoxide In dichloromethane at 5 - 20℃; for 6.5h; Reagent/catalyst;	92.5%

mesytaldehyde (487-68-3) + Diphenylphosphine oxide (4559-70-0) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: mesytaldehyde; Diphenylphosphine oxide In dichloromethane for 6h; Green chemistry; Stage #2: With ammonium metavanadate; dihydrogen peroxide at 8 - 20℃; for 5.5h; Reagent/catalyst; Green chemistry;	98%

diphenyl n-pentyloxyphosphine (39150-04-4) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 9.33333h;	95.8%

(sec-butyloxy)di(phenyl)phosphine (65119-90-6) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 7.33333h;	95.6%

Ethyl diphenylphosphinite (719-80-2) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 40 - 90℃; for 8h; Time; Green chemistry;	95.1%
With N,N-dimethyl-cyclohexanamine at 80 - 85℃; Product distribution / selectivity;

diphenyl n-propoxyphosphine (92556-46-2) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 7.33333h;	95.1%

diphenyl sec-pentyloxyphosphine (38011-61-9) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 7.33333h;	94.9%

(n-butyloxy)di(phenyl)phosphine (13360-94-6) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 9.33333h;	94.8%

(2,4,6-trimethylbenzyl)diphenylphosphine oxide (149731-53-3) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With tert.-butylhydroperoxide; bis(acetylacetonate)oxovanadium In dichloromethane at 20℃;	94%

ethanol (64-17-5) + chloro-diphenylphosphine (1079-66-9) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: ethanol With sodium In toluene at 65 - 70℃; for 2h; Stage #2: chloro-diphenylphosphine In toluene at 5 - 10℃; for 1h; Stage #3: mesitylene-2-carboxylic acid chloride In toluene at 70 - 75℃; for 5h; Temperature; Solvent;	92.2%

(trichloromethyl)mesitylene (707-74-4) + chloro-diphenylphosphine (1079-66-9) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: chloro-diphenylphosphine With potassium hydroxide In toluene at 20℃; for 2.5h; Inert atmosphere; Stage #2: (trichloromethyl)mesitylene With iron(III) chloride at 90℃; Inert atmosphere;	91%
Stage #1: (trichloromethyl)mesitylene; chloro-diphenylphosphine With magnesium In tetrahydrofuran Reflux; Stage #2: With hydrogenchloride; dihydrogen peroxide In water	87 g

isopropyl diphenylphosphinite (27350-46-5) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
at 50 - 90℃; for 7.33333h;	90.7%

(trichloromethyl)mesitylene (707-74-4) + Diphenylphosphine oxide (4559-70-0) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: (trichloromethyl)mesitylene; Diphenylphosphine oxide With iron(III) chloride In toluene at 90℃; for 3h; Inert atmosphere; Stage #2: With water; sodium hydrogencarbonate In toluene at 20℃; Inert atmosphere;	89%
Stage #1: Diphenylphosphine oxide With n-butyllithium In tetrahydrofuran for 0.5h; Cooling with ice; Stage #2: (trichloromethyl)mesitylene In tetrahydrofuran for 0.5h;	87%

Diphenylphosphine oxide (4559-70-0) + mesitylene-2-carboxylic acid chloride (938-18-1) → C34H32O3P2 + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With potassium hydroxide In 1,2-dichloro-ethane at -10℃; Solvent; Reagent/catalyst; Temperature; Inert atmosphere;	A 8% B 89%

Diphenylphosphine oxide (4559-70-0) + mesitylene-2-carboxylic acid chloride (938-18-1) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With dmap at 80℃;	88.2%
With Methyltrichlorosilane; triethylamine In 1,4-dioxane at 60℃; Catalytic behavior; Reagent/catalyst; Solvent; Temperature; Schlenk technique; Inert atmosphere; Green chemistry;	71%
Stage #1: mesitylene-2-carboxylic acid chloride With aluminum (III) chloride In 1,2-dichloro-ethane at 20℃; for 1h; Inert atmosphere; Stage #2: Diphenylphosphine oxide In 1,2-dichloro-ethane for 5h; Reflux;	1.6 g

C22H21Cl2P → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With dihydrogen peroxide In toluene	84%

tetrachloromethane (56-23-5) + Diphenylphosphine oxide (4559-70-0) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: tetrachloromethane; 1,3,5-trimethyl-benzene With aluminum (III) chloride at 40℃; for 3.25h; Inert atmosphere; Stage #2: With hydrogenchloride; water at 20℃; for 0.5h; Inert atmosphere; Stage #3: Diphenylphosphine oxide In toluene Reagent/catalyst; Inert atmosphere;	84%

diphenylphosphinous acid methyl ester (4020-99-9) + 2,2,2-trichloro-1-(2,4,6-trimethylphenyl)ethan-1-one (81759-79-7) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
In toluene at 40 - 60℃;	82%

Ethyl diphenylphosphinite (719-80-2) + 2,2,2-trichloro-1-(2,4,6-trimethylphenyl)ethan-1-one (81759-79-7) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
In toluene at 40 - 60℃;	81%

tetrachloromethane (56-23-5) + chloro-diphenylphosphine (1079-66-9) + 1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: tetrachloromethane; 1,3,5-trimethyl-benzene With aluminum (III) chloride at 40℃; for 3.25h; Inert atmosphere; Stage #2: With hydrogenchloride; water at 20℃; for 0.5h; Inert atmosphere; Stage #3: chloro-diphenylphosphine Further stages;	81%

mesytaldehyde (487-68-3) + benzene (71-43-2) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Stage #1: benzene With aluminum (III) chloride; phosphorus trichloride at 70 - 120℃; Stage #2: mesytaldehyde at 5 - 10℃; Stage #3: With tungsten trioxide; tetrabutylammomium bromide; dihydrogen peroxide; sodium hydroxide at 5 - 10℃; pH=2;	80%

1,3,5-trimethyl-benzene (108-67-8) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride; hydrogenchloride / 2 h / 20 °C 2: magnesium / tetrahydrofuran / Reflux View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / 3 h / 20 - 45 °C 2.1: n-butyllithium / tetrahydrofuran / 0.5 h / Cooling with ice 2.2: 0.5 h View Scheme
Multi-step reaction with 3 steps 1.1: aluminum (III) chloride / 3 h / 20 - 45 °C 2.1: lithium / tetrahydrofuran / 35 °C / Inert atmosphere 2.2: 20 °C 3.1: dihydrogen peroxide / toluene View Scheme
Multi-step reaction with 2 steps 1.1: C8H15N2(1+)*Br(1-)*2AlCl3; titanium tetrachloride; 1-methylimidazole hydrogen sulfate / 20 °C / 22502.3 - 30003 Torr / Autoclave 2.1: water; chlorobenzene / 2 h / 5 - 20 °C 2.2: 20 h / 5 °C / pH 3 View Scheme

(trichloromethyl)mesitylene (707-74-4) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1.1: lithium / tetrahydrofuran / 35 °C / Inert atmosphere 1.2: 20 °C 2.1: dihydrogen peroxide / toluene View Scheme

2,4,6-trimethylbenzyl alcohol (4170-90-5) + Diphenylphosphine oxide (4559-70-0) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: dipotassium peroxodisulfate / acetone / 20 °C 2: manganese(IV) oxide / dichloromethane / 20 °C View Scheme

mesitylene-2-carboxylic acid chloride (938-18-1) + diphenyl(methyl)phosphine oxide (2129-89-7) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
In toluene at 0 - 80℃; for 3h; Inert atmosphere;
In toluene at 0 - 80℃; for 3h; Inert atmosphere;

benzene (71-43-2) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: aluminum (III) chloride; trichlorophosphate / 4 h / 70 °C / Inert atmosphere 2: dmap / 80 °C View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; trichlorophosphate / 70 - 120 °C 1.2: 0.5 h / 30 °C 2.1: toluene / 40 - 60 °C View Scheme
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride; trichlorophosphate / 70 - 130 °C 1.2: 0.5 h / 30 °C 2.1: toluene / 40 - 60 °C View Scheme

diphenylphosphanyl(2,4,6-trimethylphenyl)methanone → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
With dihydrogen peroxide In diethyl ether at 30 - 45℃; for 2h; Inert atmosphere;	59.3g
With tert.-butylhydroperoxide; vanadia In chlorobenzene at 30℃; under 1500.15 Torr; for 0.00138889h; Temperature; Reagent/catalyst;
With 3-chloro-benzenecarboperoxoic acid In tetrahydrofuran at 25℃; for 3h; Inert atmosphere;

chloro-diphenylphosphine (1079-66-9) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole / 2 h / 35 - 60 °C 2: 7.33 h / 50 - 90 °C View Scheme
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole / 2 h / 45 - 65 °C 2: 9.33 h / 50 - 90 °C View Scheme
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole / 2 h / 50 - 100 °C 2: 7.33 h / 50 - 90 °C View Scheme
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole / 2 h / 50 - 65 °C 2: 7.33 h / 50 - 90 °C View Scheme
Multi-step reaction with 2 steps 1: 1-methyl-1H-imidazole / 3 h / 50 - 80 °C 2: 9.33 h / 50 - 90 °C View Scheme

mesytaldehyde (487-68-3) + chloro-diphenylphosphine (1079-66-9) → (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8)

Conditions	Yield
Multi-step reaction with 2 steps 1: chlorobenzene / 0 h / 30 °C / 1500.15 Torr 2: vanadia; tert.-butylhydroperoxide / chlorobenzene / 0 h / 30 °C / 1500.15 Torr View Scheme
Stage #1: mesytaldehyde; chloro-diphenylphosphine In water; chlorobenzene at 5 - 20℃; for 2h; Stage #2: With ammonium molibdate; tetrabutylammomium bromide; dihydrogen peroxide; sodium hydroxide In water; chlorobenzene at 5℃; for 20h; pH=3;

(2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) + 2-chloropropionyl chloride (625-36-5) → C25H24ClO3P

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 10 - 35℃; for 7h;	99%

1-iodoperfluorododecane (307-60-8) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → pentacosafluorododecyldiphenylphosphine (1424373-37-4)

Conditions	Yield
With Diphenylphosphine oxide at 20℃; for 6h; Inert atmosphere; Irradiation;	98%

(2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → diphenyl(2,4,6-trimethylphenyl)phosphine oxide (91239-43-9)

Conditions	Yield
With tris-(dibenzylideneacetone)dipalladium(0); tricyclohexylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 130℃; for 16h; Schlenk technique; Inert atmosphere;	97%

1-Iodo-perfluorodecane (423-62-1) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → henicosafluorodecyldiphenylphosphine

Conditions	Yield
With Diphenylphosphine oxide at 20℃; for 1.5h; Wavelength; Reagent/catalyst; Time; Inert atmosphere; Irradiation;	96%
With diphenylphosphane at 20℃; for 3.5h; Wavelength; Irradiation; Inert atmosphere; Sealed tube;	81 %Spectr.
In chloroform-d1 at 15 - 25℃; for 3.5h; Solvent; Irradiation; Sealed tube;	41 %Spectr.

dodecafluoro-1,6-diiodohexane (375-80-4) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → 1,6-bis(diphenylthiophosphinyl)perfluorohexane (1424373-26-1)

Conditions	Yield
Stage #1: dodecafluoro-1,6-diiodohexane; (2,4,6-trimethylbenzoyl)diphenylphosphine oxide With Diphenylphosphine oxide at 20℃; for 6h; Inert atmosphere; Irradiation; Stage #2: With sulfur at 80℃; for 5h; Inert atmosphere;	96%

4,4'-dimethoxyphenyl disulfide (5335-87-5) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → S-(4-methoxyphenyl) 2,4,6-trimethylthiobenzoate + S-(4-methoxyphenyl)thiodiphenylphosphorus oxide (99234-85-2)

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 87% B 96%

(2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) + diphenyldisulfane (882-33-7) → S-phenyl 2,4,6-trimethylthiobenzoate (50404-53-0) + diphenylthiophosphinic acid-S-phenyl ester (5510-78-1)

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 78% B 95%

1-Iodo-perfluorodecane (423-62-1) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) + diphenylphosphane (829-85-6) → henicosafluorodecyldiphenylphosphine

Conditions	Yield
at 20℃; for 1.5h; Irradiation;	95%
In chloroform-d1 at 15 - 25℃; for 1.5h; Irradiation; Sealed tube;	88%

di(p-tolyl) disulfide (103-19-5) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → S-(4-methylphenyl)thiodiphenylphosphorus oxide (5510-81-6) + S-(4-methylphenyl) 2,4,6-trimethylthiobenzoate

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 94% B 94%

bis(p-chlorophenyl) diselenide (20541-49-5) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → Se-(4-chlorophenyl) 2,4,6-trimethylselenobenzoate + Se-(4-chlorophenyl) diphenylselenophosphinate

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 94% B 92%

dibutyl diselenide (20333-40-8) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → P,P-diphenylphosphinoselenoic acid Se-butyl ester + Se-(n-butyl) 2,4,6-trimethylselenobenzoate

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 91% B 94%

diphenyl diselenide (1666-13-3) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → Se-phenyl diphenylselenophosphinate (2049-62-9) + Se-phenyl 2,4,6-trimethylselenobenzoate

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 92% B 88%

(2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) + chloroacetyl chloride (79-04-9) → C24H22ClO3P

Conditions	Yield
With aluminum (III) chloride In dichloromethane at 10 - 35℃; for 7h;	92%

dibenzyl disulphide (150-60-7) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) → diphenylphosphinothioic acid S-benzyl ester (3096-05-7) + C17H18OS

Conditions	Yield
In dichloromethane at 20℃; for 6h; Inert atmosphere; Sealed tube; Irradiation;	A 91% B 40 %Spectr.

1-Iodo-perfluorodecane (423-62-1) + (2,4,6-trimethylbenzoyl)diphenylphosphine oxide (75980-60-8) + Diphenylphosphine oxide (4559-70-0) → henicosafluorodecyldiphenylphosphine

Conditions	Yield
at 20℃; for 1.5h; Irradiation;	90%
In chloroform-d1 at 15 - 25℃; for 1.5h; Irradiation;	90%

Upstream product

• 719-80-2 Ethyl diphenylphosphinite 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 707-74-4 (trichloromethyl)mesitylene 
• 1079-66-9 chloro-diphenylphosphine 
• 4559-70-0 Diphenylphosphine oxide 
• 4170-90-5 2,4,6-trimethylbenzyl alcohol 
• 64-17-5 ethanol 
• 487-68-3 mesytaldehyde 
• 71-43-2 benzene 
• 2129-89-7 diphenyl(methyl)phosphine oxide 
• 65119-90-6 (sec-butyloxy)di(phenyl)phosphine 
• 92556-46-2 diphenyl n-propoxyphosphine 
• 27350-46-5 isopropyl diphenylphosphinite 

Downstream Products

• 120292-24-2 C₃₄H₃₁O₃P₂ 
• 12771-59-4 diphenylphosphinoyl radical 
• 4746-81-0 mesitil 
• 1054-59-7 1,1,2,2-tetraphenyldiphosphane-1,2-dioxide 
• 178817-23-7 diphenylphosphinic-diphenylphosphinous anhydride 
• 72666-10-5 diphenyl<(2,4,6-trimethylbenzoyl)oxy>phosphine 
• 4559-70-0 Diphenylphosphine oxide 
• 67992-95-4 2,4,6-trimethylbenzoyl radical 
• 1146356-11-7 (diphenylphosphoryl){2-[5,6-bis(4-bromophenyl)-1,2,4-triazin-3-yl]hydrazino} (2,4,6-trimethylphenyl)methanol 
• 1146356-13-9 7,8-bis(4-bromophenyl)-4,4-diphenyl-3-(2,4,6-trimethylphenyl)-4H-4λ5-1,2,4-triazino[3,2-c][1,2,4,5]triazaphosphinin-4-ol 
• 1233349-89-7 (4-bromomethyl-2,6-dimethylphenyl)(diphenylphosphinoyl)methanone 
• 1424373-37-4 pentacosafluorododecyldiphenylphosphine 
• 1202071-48-4 heptadecafluorooctyldiphenylphosphine 
• 1424373-26-1 1,6-bis(diphenylthiophosphinyl)perfluorohexane 

Relevant academic research and scientific papers

Effective Catalyst for Oxidation Synthesis of 2,4,6-Trimethylbenzoyldipenylphosphine Oxide: V/MCM-41

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High performance liquid phase continuous automatic production and co-production technology of organic phosphine compound

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Method for catalytically synthesizing benzoyl phosphine oxide compound

The invention discloses a method for catalytically synthesizing a benzoyl phosphine oxide compound, and belongs to the technical field of chemical engineering. According to the method, trimethylchlorosilane is taken as a catalyst, a halogen-containing compound is taken as a cocatalyst, reaction of a phosphine oxide compound and 2, 4, 6-trimethylbenzoyl chloride is realized in a proper solvent at a certain temperature, and the benzoyl phosphine oxide compound (represented by 2, 4, 6-trimethylbenzoyl diphenyl phosphine oxide (TPO for short) is prepared with high selectivity. The process has the characteristics of mild reaction conditions and high quality of the prepared product. The method does not involve a violent oxidation process, does not generate toxic waste gas, is simple and convenient to operate in the whole process, is environment-friendly and is particularly suitable for industrial mass production.

Efficient preparation method of 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide

The invention discloses an efficient preparation method of 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide, which comprises the following steps: reacting 2, 4, 6-trimethylbenzaldehyde and diphenyl phosphine oxide in ethanol at room temperature for 24 hours to obtain a 2, 4, 6-trimethylphenyl diphenyl phosphine oxide-based methanol raw material; by adopting a catalyst, a solvent and an oxidant, reacting a separated and purified 2, 4, 6-trimethylphenyl diphenyl phosphine oxide-based methanol raw material at room temperature for 12 hours; evaporating to remove the acetic acid solvent, and recrystallizing with ethyl acetate and n-hexane to obtain pure 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide (TPO) crystals. According to the technical scheme, the use amount of the oxidation catalystis small, conditions are mild, operation is convenient and rapid, decomposition of the 2, 4, 6-trimethylphenyl diphenyl phosphine oxide-based methanol raw material or deterioration of the 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide product is avoided, and the 2, 4, 6-trimethylbenzoyl-diphenyl phosphine oxide target product is obtained with high yield and high purity.

Conversion of α‐hydroxy(2,4,6‐trimethylbenzyl)diphenylphosphine oxide to TPO: oxidation vs decomposition

This study details the oxidation of α-hydroxy(2,4,6-trimethylbenzyl)diphenylphosphine oxide (α-HDPO) to diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) by choosing the proper MnO2 as oxidant. In addition, the equilibrium of α-HDPO and 2,4

New preparation method of first-class phenyl phosphine oxide initiator

The invention provides a new preparation method of a first-class phenyl phosphine oxide initiator. The method comprises the steps that (1) benzene and aluminum trichloride are added into a reaction vessel and stirred uniformly, then phosphorus trichloride is added, the temperature is slowly increased, and after a complete reaction, the temperature is reduced to room temperature; (2) a reaction mixture obtained in the step (1) is slowly added dropwise into a solvent containing a decomplexing agent, and the temperature is controlled for decomplexing; (3) a decomplexing product obtained in the step (2) is filtered to separate solids, and filtrate is subjected to pressure reduction distillation to obtain phenyl dialkoxy phosphine or diphenyl alkoxy phosphine; (4) a product obtained in the step(3) is dissolved in a benzene or methylbenzene solvent, and a trichloromethyl acetyl compound is added dropwise for a reaction; and (5) a solution obtained after the complete reaction in the step (4)is subjected to low-pressure desolvation, and light-yellow liquid or solid, namely the phenyl phosphine oxide initiator, is obtained through crystallization, suction filtering and drying. The methodhas the advantages that raw materials are easy to obtain, cost is low, operation is easy to perform, and mass production can be realized.