High Resolution NMR Spectroscopic Studies on the Metabolism and Futile Deacetylation of 4-Hydroxyacetanilide (Paracetamol) in the Rat

Article abstract of DOI:10.1016/0006-2952(95)98513-9

Paracetamol (4-hydroxyacetanilide, acetaminophen) was synthesized with the acetyl group labelled with C²H₃ (paracetamol-C²H₃), and dosed to rats i.p. at 25 mg/kg (N = 5) and 40 mg/kg (N = 3) body weight. Paracet