60902-28-5Relevant articles and documents
High Resolution NMR Spectroscopic Studies on the Metabolism and Futile Deacetylation of 4-Hydroxyacetanilide (Paracetamol) in the Rat
Nicholls, Andrew W.,Caddick, Stephen,Wilson, Ian D.,Farrant, R. Duncan,Lindos, John C.,Nicholson, Jeremy K.
, p. 1155 - 1164 (1995)
Paracetamol (4-hydroxyacetanilide, acetaminophen) was synthesized with the acetyl group labelled with C2H3 (paracetamol-C2H3), and dosed to rats i.p. at 25 mg/kg (N = 5) and 40 mg/kg (N = 3) body weight. Paracet
Preparation of labeled human drugmetabolites and drug-drug interaction-probes with fungal peroxygenases
Poraj-Kobielska, Marzena,Atzrodt, Jens,Holla, Wolfgang,Sandvoss, Martin,Groebe, Glenn,Scheibner, Katrin,Hofrichter, Martin
, p. 513 - 519 (2014/03/21)
Enzymatic conversion of a drug can be an efficient alternative for the preparation of a complex metabolite compared with a multi-step chemical synthesis approach. Limitations exist for chemical methods for direct oxygen incorporation into organic molecule