Highly efficient and versatile synthesis of libraries of constrained β- strand mimetics

DOI: 10.1016/S0960-894X(98)00420-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2321 - 2326 (1998)

Update date:2022-08-16

Topics:

Authors:

Ogbu, Cyprian O.

Qabar, Maher N.

Boatman, P. Douglas

Urban, Jan

Meara, Joseph P.

Ferguson, Mark D.

Tulinsky, John

Lum, Chris

Babu, Suresh

Blaskovich, Mark A.

Nakanishi, Hiroshi

Ruan, Fuqiang

Cao, Bolong

Minarik, Ryan

Little, Tom

Nelson, Sherry

Nguyen, Minh

Gall, Anna

Kahn, Michael

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Article abstract of DOI:10.1016/S0960-894X(98)00420-X

The general approach of using a bicyclic template to produce inhibitors of the protease superfamily of enzymes has been investigated. The Diels- Alder cycloaddition reaction on solid support has been found to be highly efficient for the synthesis of libra

Full text of DOI:10.1016/S0960-894X(98)00420-X

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Product name:1H-[1,2,4]Triazolo[1,2-a]pyridazine-5-carboxylic acid, 2,3,5,8-tetrahydro-1,3-dioxo-2-phenyl-

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