A synthetic approach to benanomicin A. 1. Synthesis of 5,6-dihydrobenzo[a] naphthacenequinone

Article abstract of DOI:10.7164/antibiotics.50.685

5,6-Dihydrobenzo[a] naphthacenequinone has been constructed by DIELS-ALDER reaction of an outer-ring diene with a naphthoquinone regioselectively. Similarly, the 14-hydroxy-5,6-dihydrobenzo[a] naphthacenequinone has also been synthesized via the reaction of vinylketene acetal with naphthoquinone.